7byj: Difference between revisions
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==Crystal structure of the FERM domain of FRMPD4== | ==Crystal structure of the FERM domain of FRMPD4== | ||
<StructureSection load='7byj' size='340' side='right'caption='[[7byj]]' scene=''> | <StructureSection load='7byj' size='340' side='right'caption='[[7byj]], [[Resolution|resolution]] 2.49Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7BYJ OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=7BYJ FirstGlance]. <br> | <table><tr><td colspan='2'>[[7byj]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7BYJ OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=7BYJ FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=7byj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7byj OCA], [http://pdbe.org/7byj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=7byj RCSB], [http://www.ebi.ac.uk/pdbsum/7byj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=7byj ProSAT]</span></td></tr> | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">FRMPD4, KIAA0316, PDZD10, PDZK10 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=7byj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7byj OCA], [http://pdbe.org/7byj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=7byj RCSB], [http://www.ebi.ac.uk/pdbsum/7byj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=7byj ProSAT]</span></td></tr> | |||
</table> | </table> | ||
== Disease == | |||
[[http://www.uniprot.org/uniprot/FRPD4_HUMAN FRPD4_HUMAN]] The disease is caused by mutations affecting the gene represented in this entry. | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/FRPD4_HUMAN FRPD4_HUMAN]] Positive regulator of dendritic spine morphogenesis and density. Required for the maintenance of excitatory synaptic transmission. Binds phosphatidylinositol 4,5-bisphosphate.<ref>PMID:19118189</ref> | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
Scaffold proteins play crucial roles in orchestrating synaptic signaling and plasticity in the excitatory synapses by providing a structural link between glutamatergic receptors, signaling molecules, and neuronal cytoskeletons. FRMPD4 is a neural scaffold protein that binds to metabotropic glutamate receptors via its FERM domain. Here, we determine the crystal structure of the FERM domain of FRMPD4 at 2.49 A resolution. The structure reveals that the canonical target binding groove of FRMPD4 FERM is occupied by a conserved fragment C-terminal to the FERM domain, suggesting that the FRMPD4-mGluR interaction may adopt a distinct binding mode. In addition, FRMPD4 FERM does not contain a typical phosphoinositide binding site at the F1/F3 cleft found in ERM family FERM domains, but it possesses a conserved basic residue cluster on the F2 lobe which could bind to lipid effectively. Finally, analysis of mutations that are associated with X-linked intellectual disability suggests that they may compromise the biological function of FRMPD4 by destabilizing the FERM structure. | |||
Structure of the FERM domain of a neural scaffold protein FRMPD4 implicated in X-linked intellectual disability.,Wang M, Lin L, Shi Y, He L, Wang C, Zhu J Biochem J. 2020 Dec 11;477(23):4623-4634. doi: 10.1042/BCJ20200857. PMID:33216857<ref>PMID:33216857</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
<div class="pdbe-citations 7byj" style="background-color:#fffaf0;"></div> | |||
== References == | |||
<references/> | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Human]] | |||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Lin L]] | [[Category: Lin, L]] | ||
[[Category: Wang C]] | [[Category: Wang, C]] | ||
[[Category: Wang M]] | [[Category: Wang, M]] | ||
[[Category: Zhu J]] | [[Category: Zhu, J]] | ||
[[Category: Ferm]] | |||
[[Category: Frmpd4]] | |||
[[Category: Neural scaffold protein]] | |||
[[Category: Protein binding]] | |||
Revision as of 07:04, 30 December 2020
Crystal structure of the FERM domain of FRMPD4
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