1day: Difference between revisions

Line 1:

[[Image:1day.~~jpg~~|left|200px]]

[[Image:1day.png|left|200px]]

<!--

Line 9:

Line 10:

~~'''~~CRYSTAL STRUCTURE OF A BINARY COMPLEX OF PROTEIN KINASE CK2 (ALPHA-SUBUNIT) AND MG-GMPPNP~~'''~~

===CRYSTAL STRUCTURE OF A BINARY COMPLEX OF PROTEIN KINASE CK2 (ALPHA-SUBUNIT) AND MG-GMPPNP===

~~==Overview==~~

<!--

The ~~structures of~~ the ~~catalytic subunit of protein kinase CK2 from Zea mays complexed with Mg2+ and with analogs of ATP or GTP were determined~~ to 2.~~2 A resolution~~. ~~Unlike most other protein kinases, CK2 from various sources shows 'dual-cosubstrate specificity'~~, ~~that~~ is, the ~~ability to efficiently use either ATP or GTP as a cosubstrate~~. ~~The structures of these complexes demonstrate that water molecules are critical to switch the active site of CK2 from an ATP~~- ~~to a GTP~~-~~compatible state. An understanding of the structural basis of dual-cosubstrate specificity may help in the design of drugs that target CK2 or other kinases with this property.~~

The line below this paragraph, {{ABSTRACT_PUBMED_10581548}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 10581548 is the PubMed ID number.

-->

==About this Structure==

Line 31:

Line 35:

[[Category: Dual-cosubstrate specificity]]

[[Category: Protein kinase ck2]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Fri May 2 13~~:38:37 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 22:45:43 2008''

Navigation menu

Page actions

Page actions

Personal tools

Navigation

Search

Tools

@@ Line 1: / Line 1: @@
-[[Image:1day.jpg|left|200px]]
+{{Seed}}
+[[Image:1day.png|left|200px]]
 <!--
@@ Line 9: / Line 10: @@
 {{STRUCTURE_1day|  PDB=1day  |  SCENE=  }}
-'''CRYSTAL STRUCTURE OF A BINARY COMPLEX OF PROTEIN KINASE CK2 (ALPHA-SUBUNIT) AND MG-GMPPNP'''
+===CRYSTAL STRUCTURE OF A BINARY COMPLEX OF PROTEIN KINASE CK2 (ALPHA-SUBUNIT) AND MG-GMPPNP===
-==Overview==
+<!--
-The structures of the catalytic subunit of protein kinase CK2 from Zea mays complexed with Mg2+ and with analogs of ATP or GTP were determined to 2.2 A resolution. Unlike most other protein kinases, CK2 from various sources shows 'dual-cosubstrate specificity', that is, the ability to efficiently use either ATP or GTP as a cosubstrate. The structures of these complexes demonstrate that water molecules are critical to switch the active site of CK2 from an ATP- to a GTP-compatible state. An understanding of the structural basis of dual-cosubstrate specificity may help in the design of drugs that target CK2 or other kinases with this property.
+The line below this paragraph, {{ABSTRACT_PUBMED_10581548}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 10581548 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_10581548}}
 ==About this Structure==
@@ Line 31: / Line 35: @@
 [[Category: Dual-cosubstrate specificity]]
 [[Category: Protein kinase ck2]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 13:38:37 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 22:45:43 2008''