1dbr: Difference between revisions

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[[Image:1dbr.jpg|left|200px]]
{{Seed}}
[[Image:1dbr.png|left|200px]]


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{{STRUCTURE_1dbr|  PDB=1dbr  |  SCENE=  }}  
{{STRUCTURE_1dbr|  PDB=1dbr  |  SCENE=  }}  


'''HYPOXANTHINE GUANINE XANTHINE'''
===HYPOXANTHINE GUANINE XANTHINE===




==Overview==
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Crystal structures of substrate-free and XMP-soaked hypoxanthine-guanine-xanthine phosphoribosyltransferase (HGXPRTase) of the opportunistic pathogen Toxoplasma gondii have been determined to 2.4 and 2.9 A resolution, respectively. HGXPRTase displays the conserved PRTase fold. In the structure of the enzyme bound to its product, a long flexible loop (residues 115-126) is located away from the active site. Comparison to the substrate-free structure reveals a striking relocation of the loop, which is poised to cover the catalytic pocket, thus providing a mechanism by which the HG(X)PRTases shield their oxocarbonium transition states from nucleophilic attack by the bulk solvent. The conserved Ser 117-Tyr 118 dipeptide within the loop is brought to the active site, completing the ensemble of catalytic residues.
The line below this paragraph, {{ABSTRACT_PUBMED_8836106}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 8836106 is the PubMed ID number.
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{{ABSTRACT_PUBMED_8836106}}


==About this Structure==
==About this Structure==
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[[Category: Purine salvage]]
[[Category: Purine salvage]]
[[Category: Transferase]]
[[Category: Transferase]]
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