7b6i: Difference between revisions
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==Crystal structure of MurE from E.coli in complex with Z1373445602== | ==Crystal structure of MurE from E.coli in complex with Z1373445602== | ||
<StructureSection load='7b6i' size='340' side='right'caption='[[7b6i]]' scene=''> | <StructureSection load='7b6i' size='340' side='right'caption='[[7b6i]], [[Resolution|resolution]] 2.07Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7B6I OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=7B6I FirstGlance]. <br> | <table><tr><td colspan='2'>[[7b6i]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7B6I OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=7B6I FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=7b6i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7b6i OCA], [http://pdbe.org/7b6i PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=7b6i RCSB], [http://www.ebi.ac.uk/pdbsum/7b6i PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=7b6i ProSAT]</span></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene>, <scene name='pdbligand=IPA:ISOPROPYL+ALCOHOL'>IPA</scene>, <scene name='pdbligand=SZE:4-(3-fluoranylpyridin-2-yl)-1-methyl-piperazin-2-one'>SZE</scene></td></tr> | ||
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate_ligase UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.2.13 6.3.2.13] </span></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=7b6i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7b6i OCA], [http://pdbe.org/7b6i PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=7b6i RCSB], [http://www.ebi.ac.uk/pdbsum/7b6i PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=7b6i ProSAT]</span></td></tr> | |||
</table> | </table> | ||
== Function == | |||
[[http://www.uniprot.org/uniprot/MURE_ECOLI MURE_ECOLI]] Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan. Is also able to use many meso-diaminopimelate analogs as substrates, although much less efficiently, but not L-lysine.<ref>PMID:2269304</ref> <ref>PMID:3905407</ref> <ref>PMID:11124264</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Arrowsmith | [[Category: UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase]] | ||
[[Category: Bountra C]] | [[Category: Arrowsmith, C H]] | ||
[[Category: Edwards | [[Category: Bountra, C]] | ||
[[Category: Fairhead M]] | [[Category: Delft, F von]] | ||
[[Category: Koekemoer L]] | [[Category: Douangamath, A]] | ||
[[Category: Krojer T]] | [[Category: Edwards, A M]] | ||
[[Category: Steindel M]] | [[Category: Fairhead, M]] | ||
[[Category: | [[Category: Koekemoer, L]] | ||
[[Category: Krojer, T]] | |||
[[Category: Structural genomic]] | |||
[[Category: Steindel, M]] | |||
[[Category: Talon, R]] | |||
[[Category: 6-diaminopimelate ligase cell wall biosynthesis ligase drug target]] | |||
[[Category: Biosynthetic protein]] | |||
[[Category: Fragment screening]] | |||
[[Category: Sgc]] | |||
[[Category: Udp-n-acetylmuramoyl-l-alanyl-d-glutamate-2]] | |||
