1ddp: Difference between revisions

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[[Image:1ddp.gif|left|200px]]
{{Seed}}
[[Image:1ddp.png|left|200px]]


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{{STRUCTURE_1ddp|  PDB=1ddp  |  SCENE=  }}  
{{STRUCTURE_1ddp|  PDB=1ddp  |  SCENE=  }}  


'''SOLUTION STRUCTURE OF A CISPLATIN-INDUCED [CATAGCTATG]2 INTERSTRAND CROSS-LINK'''
===SOLUTION STRUCTURE OF A CISPLATIN-INDUCED [CATAGCTATG]2 INTERSTRAND CROSS-LINK===




==Overview==
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The widely used antitumor drug cis-diamminedichloroplatinum(II) (cisplatin or cis-DDP) reacts with DNA, cross-linking two purine residues through the N7 atoms, which reside in the major groove in B-form DNA. The solution structure of the short duplex [d(CAT-AGCTATG)]2 cross-linked at the GC:GC site was determined by nuclear magnetic resonance (NMR). The deoxyguanosine-bridging cis-diammineplatinum(II) lies in the minor groove, and the complementary deoxycytidines are extrahelical. The double helix is locally reversed to a left-handed form, and the helix is unwound and bent toward the minor groove. These findings were independently confirmed by results from a phase-sensitive gel electrophoresis bending assay. The NMR structure differs markedly from previously proposed models but accounts for the chemical reactivity, the unwinding, and the bending of cis-DDP interstrand cross-linked DNA and may be important in the formation and repair of these cross-links in chromatin.
The line below this paragraph, {{ABSTRACT_PUBMED_8525382}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 8525382 is the PubMed ID number.
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{{ABSTRACT_PUBMED_8525382}}


==About this Structure==
==About this Structure==
Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DDP OCA].  
Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DDP OCA].  


==Reference==
==Reference==
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[[Category: Interstrand cross-link]]
[[Category: Interstrand cross-link]]
[[Category: Nmr]]
[[Category: Nmr]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 13:44:08 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 22:52:27 2008''

Revision as of 19:52, 30 June 2008

File:1ddp.png

Template:STRUCTURE 1ddp

SOLUTION STRUCTURE OF A CISPLATIN-INDUCED [CATAGCTATG]2 INTERSTRAND CROSS-LINK

Template:ABSTRACT PUBMED 8525382

About this Structure

Full experimental information is available from OCA.

Reference

Solution structure of a cisplatin-induced DNA interstrand cross-link., Huang H, Zhu L, Reid BR, Drobny GP, Hopkins PB, Science. 1995 Dec 15;270(5243):1842-5. PMID:8525382

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