1ddv: Difference between revisions

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[[Image:1ddv.gif|left|200px]]
{{Seed}}
[[Image:1ddv.png|left|200px]]


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{{STRUCTURE_1ddv|  PDB=1ddv  |  SCENE=  }}  
{{STRUCTURE_1ddv|  PDB=1ddv  |  SCENE=  }}  


'''CRYSTAL STRUCTURE OF THE HOMER EVH1 DOMAIN WITH BOUND MGLUR PEPTIDE'''
===CRYSTAL STRUCTURE OF THE HOMER EVH1 DOMAIN WITH BOUND MGLUR PEPTIDE===




==Overview==
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Homer EVH1 (Ena/VASP Homology 1) domains interact with proline-rich motifs in the cytoplasmic regions of group 1 metabotropic glutamate receptors (mGluRs), inositol-1,4,5-trisphosphate receptors (IP3Rs), and Shank proteins. We have determined the crystal structure of the Homer EVH1 domain complexed with a peptide from mGluR (TPPSPF). In contrast to other EVH1 domains, the bound mGluR ligand assumes an unusual conformation in which the side chains of the Ser-Pro tandem are oriented away from the Homer surface, and the Phe forms a unique contact. This unusual binding mode rationalizes conserved features of both Homer and Homer ligands that are not shared by other EVH1 domains. Site-directed mutagenesis confirms the importance of specific Homer residues for ligand binding. These results establish a molecular basis for understanding the biological properties of Homer-ligand complexes.
The line below this paragraph, {{ABSTRACT_PUBMED_10798399}}, adds the Publication Abstract to the page
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{{ABSTRACT_PUBMED_10798399}}


==About this Structure==
==About this Structure==
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[[Category: Polyproline recognition]]
[[Category: Polyproline recognition]]
[[Category: Protein-ligand complex]]
[[Category: Protein-ligand complex]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 13:44:26 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 22:52:44 2008''

Revision as of 19:52, 30 June 2008

File:1ddv.png

Template:STRUCTURE 1ddv

CRYSTAL STRUCTURE OF THE HOMER EVH1 DOMAIN WITH BOUND MGLUR PEPTIDE

Template:ABSTRACT PUBMED 10798399

About this Structure

1DDV is a Protein complex structure of sequences from Rattus norvegicus. Full crystallographic information is available from OCA.

Reference

Structure of the Homer EVH1 domain-peptide complex reveals a new twist in polyproline recognition., Beneken J, Tu JC, Xiao B, Nuriya M, Yuan JP, Worley PF, Leahy DJ, Neuron. 2000 Apr;26(1):143-54. PMID:10798399

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