1xpw: Difference between revisions

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<StructureSection load='1xpw' size='340' side='right'caption='[[1xpw]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
<StructureSection load='1xpw' size='340' side='right'caption='[[1xpw]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1xpw]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XPW OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1XPW FirstGlance]. <br>
<table><tr><td colspan='2'>[[1xpw]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XPW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1XPW FirstGlance]. <br>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1tvg|1tvg]]</div></td></tr>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1tvg|1tvg]]</div></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PP25 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PP25 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1xpw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xpw OCA], [http://pdbe.org/1xpw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1xpw RCSB], [http://www.ebi.ac.uk/pdbsum/1xpw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1xpw ProSAT], [http://www.topsan.org/Proteins/NESGC/1xpw TOPSAN]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1xpw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xpw OCA], [https://pdbe.org/1xpw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1xpw RCSB], [https://www.ebi.ac.uk/pdbsum/1xpw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1xpw ProSAT], [https://www.topsan.org/Proteins/NESGC/1xpw TOPSAN]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/IFT25_HUMAN IFT25_HUMAN]] Component of the IFT complex B required for sonic hedgehog/SHH signaling. May mediate transport of SHH components: required for the export of SMO and PTCH1 receptors out of the cilium and the accumulation of GLI2 at the ciliary tip in response to activation of the SHH pathway, suggesting it is involved in the dynamic transport of SHH signaling molecules within the cilium. Not required for ciliary assembly (By similarity).  
[[https://www.uniprot.org/uniprot/IFT25_HUMAN IFT25_HUMAN]] Component of the IFT complex B required for sonic hedgehog/SHH signaling. May mediate transport of SHH components: required for the export of SMO and PTCH1 receptors out of the cilium and the accumulation of GLI2 at the ciliary tip in response to activation of the SHH pathway, suggesting it is involved in the dynamic transport of SHH signaling molecules within the cilium. Not required for ciliary assembly (By similarity).  
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]