Sandbox Reserved 1653: Difference between revisions
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in blood vessel endothelial cells and is implicated in the development and physiological functions of the circulatory system, including the proper | in blood vessel endothelial cells and is implicated in the development and physiological functions of the circulatory system, including the proper | ||
formation of blood, vessels, regulation of vascular tone and remodelling of small resistance arteries upon hypertension. It’s also involved in red blood | formation of blood, vessels, regulation of vascular tone and remodelling of small resistance arteries upon hypertension. It’s also involved in red blood | ||
cell volume homeostasis. | cell volume homeostasis. <ref> DOI 10.1016/j.cub.2017.01.048 </ref> | ||
Piezo channel mediated cationic non selective currents. Indeed, monovalent (Na+, K+) and divalent (Ca2+, Mg2+) can flow through. | Piezo channel mediated cationic non selective currents. Indeed, monovalent (Na+, K+) and divalent (Ca2+, Mg2+) can flow through. | ||
However, Piezo 1 is implicated in excitatory channels because cation can enter into the cell and lead to membrane depolarisation or calcium dependent signalling pathway (if Ca2+ enter). | However, Piezo 1 is implicated in excitatory channels because cation can enter into the cell and lead to membrane depolarisation or calcium dependent signalling pathway (if Ca2+ enter). | ||
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'''Blade''' | '''Blade''' | ||
Piezo 1 has a central domain which is composed of one CTD (C term domain), on cap (or CED), 3 inner helice (IH) and 3 outer helcice (OH). | Piezo 1 has a central domain which is composed of one CTD (C term domain), on cap (or CED), 3 inner helice (IH) and 3 outer helcice (OH). | ||
This central domain is surrounded by 3 extended arms called blades extending out from the central pore in a rotatory manner | This central domain is surrounded by 3 extended arms called blades extending out from the central pore in a rotatory manner <ref> DOI 10.4236/jbm.2019.712012 </ref>. | ||
“Each of these blade, deflecting at an angle of 100° perpendicular to the membrane, contains 6 tandems transmenbranaire helical unites (THUs) constitute | “Each of these blade, deflecting at an angle of 100° perpendicular to the membrane, contains 6 tandems transmenbranaire helical unites (THUs) constitute | ||
of 4 transmembrane domains” [6] + | of 4 transmembrane domains” [6] + <ref>DOI 10.4236/jbm.2019.712012 </ref>. “These blades are not planar: instead they lie on a spherically curved surface with the membrane bulging into the cytoplasm” [4] | ||
These blades flexibles are inside the membrane and force the membrane to curve. That why, they are considered as mechanotransduction modules, force | These blades flexibles are inside the membrane and force the membrane to curve. That why, they are considered as mechanotransduction modules, force | ||
sensors and transducers to gate the central pore. “These 3 blades propeller architecture is mechanically interesting because 3 blades are the minimum | sensors and transducers to gate the central pore. “These 3 blades propeller architecture is mechanically interesting because 3 blades are the minimum | ||
