Sandbox Reserved 1645: Difference between revisions

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==Fibrillin - 1==
==Fibrillin - 1==
<StructureSection load='2W86' size='340' side='right' caption='3D structure of fibrillin-1' scene=''>
<StructureSection load='2W86' size='340' side='right' caption='3D structure of fibrillin-1' scene=''>
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You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID:21638687</ref> to the rescue.


Fibrillin-1 (PDB ID: 2W86) is a protein which is encoded in human bodies by the gene FBN1 situated on chromosome 15. Fibrillin-1 is a single protein chain of 230kb involving 65 exons from the glycoproteins' class with a mass of 350 kDa. The protein forms microfibrils located in the extracellular matrix, and thus has a role in the structural support of cells in elastic and nonelastic connective tissues in the human body.
Fibrillin-1 (PDB ID: 2W86) is a protein which is encoded in human bodies by the gene FBN1 situated on chromosome 15. Fibrillin-1 is a single protein chain of 230kb involving 65 exons from the glycoproteins' class with a mass of 350 kDa. The protein forms microfibrils located in the extracellular matrix, and thus has a role in the structural support of cells in elastic and nonelastic connective tissues in the human body.


<scene name='86/868178/Ca_cation_binding/2'>Ca 2+ binding
<scene name='86/868178/Ca_cation_binding/2'>Ca 2+ binding
</scene>
</scene>


== Structure ==
== Structure ==
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3D model represents these parts of fibrillin-1: <scene name='86/868178/Cbegf9/2'>cb-EGF9</scene>, second hybrid domain and <scene name='86/868178/Cbegf10/1'>cb-EGF10</scene>.
3D model represents these parts of fibrillin-1: <scene name='86/868178/Cbegf9/2'>cb-EGF9</scene>, second hybrid domain and <scene name='86/868178/Cbegf10/1'>cb-EGF10</scene>.


== Microfibrils ==
== Microfibrils ==
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</StructureSection>
</StructureSection>
== References ==
== References ==
<references/>
1.[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4188161/ A Novel Fibrillin 1 Gene Mutation Leading to Marfan Syndrome with Minimal Cardiac Features]
2.[https://www.medecinesciences.org/en/articles/medsci/full_html/2009/02/medsci2009252p161/medsci2009252p161.html Interactions entre la Fibrilline-1 et le TGF-β]
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