Sandbox Reserved 1653: Difference between revisions
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Piezo channels comprises the C-terminal region from residues 2172 to 2547. (architecture) <ref name="architecture"> DOI 10.1038/nature15247 </ref> The CTD triangular plane has a beam-facing side of the triangular, and it is separated into two surfaces with negative and positive electrostatic potentials. (mechanogating)<ref name="mechanogating"/> | Piezo channels comprises the C-terminal region from residues 2172 to 2547. (architecture) <ref name="architecture"> DOI 10.1038/nature15247 </ref> The CTD triangular plane has a beam-facing side of the triangular, and it is separated into two surfaces with negative and positive electrostatic potentials. (mechanogating)<ref name="mechanogating"/> | ||
The beam is a 90 Å-long intracellular structure in the central region of the ion channel. It is a part of the three-bladed, propeller-shaped architecture characteristic of piezo1. It is a piece of the “beam-CTD-anchor-OH-IH” relaying interface that forms the central pore module. It is because the beam connects the THU, to the CTD and the outer helix (OH) that it enables the transmission of the mechanical force, and thus the opening of piezo1’s pore. (mechanogating)<ref name="mechanogating"/> It delivers the mechanical signals from the blades, or the plasma membrane, to the central pore module region. (structural analysis) | The beam is a 90 Å-long intracellular structure in the central region of the ion channel. It is a part of the three-bladed, propeller-shaped architecture characteristic of piezo1. It is a piece of the “beam-CTD-anchor-OH-IH” relaying interface that forms the central pore module. It is because the beam connects the THU, to the CTD and the outer helix (OH) that it enables the transmission of the mechanical force, and thus the opening of piezo1’s pore. (mechanogating)<ref name="mechanogating"/> It delivers the mechanical signals from the blades, or the plasma membrane, to the central pore module region. (structural analysis)<ref name="structural analysis"> DOI 10.4236/jbm.2019.712012 </ref> | ||
Indeed, the beams are connected to the transmembrane helical units (THUs), which forms a triangular plane above its proximal end, more precisely to the intracellular surface of THU7–THU9. The THU7-THU8 makes the largest intracellular loop of piezo1. This loop starts at the distal end of the beam, interacts with the CTD, and then folds back to the distal end of the beam before connecting to a transmembrane region. Moreover, the beam crosses through the beam-facing side of the triangular CTD, forming interactions with both CTDα 1 and CTDα 2. | Indeed, the beams are connected to the transmembrane helical units (THUs), which forms a triangular plane above its proximal end, more precisely to the intracellular surface of THU7–THU9. The THU7-THU8 makes the largest intracellular loop of piezo1. This loop starts at the distal end of the beam, interacts with the CTD, and then folds back to the distal end of the beam before connecting to a transmembrane region. Moreover, the beam crosses through the beam-facing side of the triangular CTD, forming interactions with both CTDα 1 and CTDα 2. | ||
This position and connections of the beam render it an ideal structure for mechanical transmission from the distal THUs to the central ion-conducting pore. | This position and connections of the beam render it an ideal structure for mechanical transmission from the distal THUs to the central ion-conducting pore. | ||
