Sandbox Reserved 1658: Difference between revisions
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<p align="justify">In mature organisms, neuropilins primarily perform the role of pro-angiogenic co-receptors. Neuropilin-1 works as a specific co-receptor of VEGFR-2 for VEGF-A. After binding and activation, neuropilins promote angiogenesis by stabilizing the VEGF/VEGFR binding. | <p align="justify">In mature organisms, neuropilins primarily perform the role of pro-angiogenic co-receptors. Neuropilin-1 works as a specific co-receptor of VEGFR-2 for VEGF-A. After binding and activation, neuropilins promote angiogenesis by stabilizing the VEGF/VEGFR binding. | ||
Researchers also think that neuropilins affect the vascular motility of endothelial cells, independently of their action on the protein complex VEGF/VEGFR. | Researchers also think that neuropilins affect the vascular motility of endothelial cells, independently of their action on the protein complex VEGF/VEGFR. | ||
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<h5>In neuronal development</h5> | <h5>In neuronal development</h5> | ||
<p align="justify"></p> | <p align="justify">In neuronal tissues, NRP1 associate with semaphoring-3A to perform growth cone guidance. It helps guiding axonal growth during the development of the nervous system by mediating the chemorepulsant activity of semaphorin.</p> | ||
== Disease == | == Disease == | ||
