Sandbox Reserved 1653: Difference between revisions
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<StructureSection load='5z10' size='350' side='right' caption='Piezo 1' scene=''> | <references/><StructureSection load='5z10' size='350' side='right' caption='Piezo 1' scene=''> | ||
Piezo proteins constitute a family of excitatory [[ion channels]] directly gated by mechanical forces. Piezo is functionally conserved and very important because all living organisms are subjected to mechanical forces from their environment for instance [https://en.wikipedia.org/wiki/Proprioception proprioception], [https://en.wikipedia.org/wiki/Osmoregulation osmoregulation], vascular tone, blood flow regulation, muscle [https://en.wikipedia.org/wiki/Homeostasis homeostasis], flow sensing in kidney, bladder and lungs. <ref name="Ion Permeation"> DOI 10.1016/j.neuron.2016.01.046 </ref>, | Piezo proteins constitute a family of excitatory [[ion channels]] directly gated by mechanical forces. Piezo is functionally conserved and very important because all living organisms are subjected to mechanical forces from their environment for instance [https://en.wikipedia.org/wiki/Proprioception proprioception], [https://en.wikipedia.org/wiki/Osmoregulation osmoregulation], vascular tone, blood flow regulation, muscle [https://en.wikipedia.org/wiki/Homeostasis homeostasis], flow sensing in kidney, bladder and lungs. <ref name="Ion Permeation"> DOI 10.1016/j.neuron.2016.01.046 </ref>, | ||
<ref name = "Cell Press"> DOI 10.1016/j.cub.2017.01.048 </ref> | <ref name = "Cell Press"> DOI 10.1016/j.cub.2017.01.048 </ref> | ||
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==='''Blade'''=== | ==='''Blade'''=== | ||
Piezo 1 has a central domain which is composed of <scene name='86/868186/ | Piezo 1 has a central domain which is composed of <scene name='86/868186/Cedohihctd_color/1'>one CTD, one cap (or CED), 3 inner helice (IH) and 3 outer helice (OH)</scene>. | ||
This central domain is surrounded by 3 extended arms called <scene name='86/868186/Blade/1'>blades</scene> extending out from the central pore in a rotatory manner <ref name ="Alexandra"> Zhou, Z. (2019). Structural Analysis of Piezo1 Ion Channel Reveals the Relationship between Amino Acid Sequence Mutations and Human Diseases. 139–155. DOI 10.4236/jbm.2019.712012 </ref>. | This central domain is surrounded by 3 extended arms called <scene name='86/868186/Blade/1'>blades</scene> extending out from the central pore in a rotatory manner <ref name ="Alexandra"> Zhou, Z. (2019). Structural Analysis of Piezo1 Ion Channel Reveals the Relationship between Amino Acid Sequence Mutations and Human Diseases. 139–155. DOI 10.4236/jbm.2019.712012 </ref>. | ||
"Each of these blades, deflecting at an angle of 100° perpendicular to the membrane, contains 6 tandems transmembranar helical unites (THUs) constitute | "Each of these blades, deflecting at an angle of 100° perpendicular to the membrane, contains 6 tandems transmembranar helical unites (THUs) constitute | ||
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<scene name='86/868186/Ctd/1'>CTD</scene> | <scene name='86/868186/Ctd/1'>CTD</scene> | ||
<scene name='86/868186/K2479_f2480/1'>K et F</scene> | <scene name='86/868186/K2479_f2480/1'>K et F</scene> | ||
<scene name='86/868186/Cedohihctd_color/1'>CED CTD OH IH Color</scene> | |||
</StructureSection> | </StructureSection> | ||
