Sandbox Reserved 1652: Difference between revisions
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{{Sandbox_Reserved_ESBS20_}}<!-- PLEASE ADD YOUR CONTENT BELOW HERE --> | {{Sandbox_Reserved_ESBS20_}}<!-- PLEASE ADD YOUR CONTENT BELOW HERE --> | ||
== The Transient Receptor Potential cation channel subfamily V member 1 TRPV1 == | == The Transient Receptor Potential cation channel subfamily V member 1 TRPV1 == | ||
<StructureSection load='5IS0' size='340' side='right' caption='Structure of TRPV1 in complex with capsazepine, determined in lipid nanodisc' scene='' | <StructureSection load='5IS0' size='340' side='right' caption='Structure of TRPV1 in complex with capsazepine, capsazepine is a synthetic antagonist of capsaicin, determined in lipid nanodisc' scene=''.> | ||
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[[Image:128px-Capsaicin Formulae.png | thumb|Chemical structure of capsaicin]] | [[Image:128px-Capsaicin Formulae.png | thumb|Chemical structure of capsaicin]] | ||
[https://en.wikipedia.org/wiki/Capsaicin | [https://en.wikipedia.org/wiki/Capsaicin Capsaicin] is an active compound in chili. | ||
TRPV1 receptor has a '''capsaicin-binding pocket''' formed by S3,S4 and <scene name='86/868185/S4s5_linker/1'>S4-S5 linker</scene>. The capsaicin-binding pocket is surrounded by the residues <scene name='86/868185/Y511_s512_t550/2'>Y511,S512,T550</scene>.<ref>F. Yang et J. Zheng, « Understand spiciness: mechanism of TRPV1 channel activation by capsaicin », Protein Cell, vol. 8, no 3, p. 169‑177, mars 2017, doi: 10.1007/s13238-016-0353-7.</ref> | TRPV1 receptor has a '''capsaicin-binding pocket''' formed by S3,S4 and <scene name='86/868185/S4s5_linker/1'>S4-S5 linker</scene>. The capsaicin-binding pocket is surrounded by the residues <scene name='86/868185/Y511_s512_t550/2'>Y511,S512,T550</scene>.<ref>F. Yang et J. Zheng, « Understand spiciness: mechanism of TRPV1 channel activation by capsaicin », Protein Cell, vol. 8, no 3, p. 169‑177, mars 2017, doi: 10.1007/s13238-016-0353-7.</ref> | ||
