Sandbox Reserved 1650: Difference between revisions
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Human thyroglobulin (TG) is a precursor of tetraiodothyronine or thyroxine (T4) and triiodothyronine (T3), two thyroid hormones (TH). Its structure is essential for the diagnosis, treatment and monitoring of thyroid-related diseases. | Human thyroglobulin (TG) is a precursor of tetraiodothyronine or thyroxine (T4) and triiodothyronine (T3), two thyroid hormones (TH). Its structure is essential for the diagnosis, treatment and monitoring of thyroid-related diseases. | ||
== | == Synthesis == | ||
=== | === Role and composition of the thyroid gland === | ||
The thyroid gland is an endocrine organ located in the neck that secretes HT into the bloodstream. Among them, T4 and T3 are involved in the growth, development and regulation of the metabolism of vertebrates. | The thyroid gland is an endocrine organ located in the neck that secretes HT into the bloodstream. Among them, T4 and T3 are involved in the growth, development and regulation of the metabolism of vertebrates. | ||
The thyroid gland is made up of thyroid vesicles, which in turn are made up of thyroid follicular cells that are arranged around a lumen containing a viscous substance called a colloid. The diet is a source of iodide I- ions which, once in the blood, are picked up by the thyroid cells and then partly discharged into the colloid. | The thyroid gland is made up of thyroid vesicles, which in turn are made up of thyroid follicular cells that are arranged around a lumen containing a viscous substance called a colloid. The diet is a source of iodide I- ions which, once in the blood, are picked up by the thyroid cells and then partly discharged into the colloid. | ||
=== | === Expression of the TG gene=== | ||
Thyroid follicular cells synthesize human TG via the TG gene on chromosome 8. [d-i] | Thyroid follicular cells synthesize human TG via the TG gene on chromosome 8. [d-i] | ||
