Sandbox Reserved 1660: Difference between revisions
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Additionally, there are two <scene name='86/868193/Oligosaccharides/1'>oligosaccharides</scene> bound to the alpha chain via N-glycosylations and three types of small molecules bound to that protein. CD1d molecules are structurally similar to [[Major Histocompatibility Complex Class I]], but present lipid antigens as opposed to peptides and the cleft where the ligand can bind its protein is different between MHC molecules and CD1d molecules. Indeed, the hydrophobic cleft of CD1d has a narrow opening.The recognition between the protein and its ligand occurs at a specific spot which creates an appropriate environment for the interaction to happen. This site is located at the A and F pockets in the region of the alpha helices. | Additionally, there are two <scene name='86/868193/Oligosaccharides/1'>oligosaccharides</scene> bound to the alpha chain via N-glycosylations and three types of small molecules bound to that protein. CD1d molecules are structurally similar to [[Major Histocompatibility Complex Class I]], but present lipid antigens as opposed to peptides and the cleft where the ligand can bind its protein is different between MHC molecules and CD1d molecules. Indeed, the hydrophobic cleft of CD1d has a narrow opening.The recognition between the protein and its ligand occurs at a specific spot which creates an appropriate environment for the interaction to happen. This <scene name='86/868193/Site/1'>site</scene> is located at the A and F pockets in the region of the alpha helices. | ||
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==== CD1d affinity ==== | ==== CD1d affinity ==== | ||
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CD1d proteins lipid recognition is based on the interaction of the protein with its ligand. Nevertheless, the recognition relies on two recognitions. The first one is the recognition of the head of the lipid and the second one is the recognition of the length of the molecule. Because there are more than one condition to fill in order to interact with CD1d proteins, the affinity for a lipid depends itself on a plurality of parameters which modulates it. | CD1d proteins lipid recognition is based on the interaction of the protein with its ligand. Nevertheless, the recognition relies on two recognitions. The first one is the recognition of the head of the lipid and the second one is the recognition of the length of the molecule. Because there are more than one condition to fill in order to interact with CD1d proteins, the affinity for a lipid depends itself on a plurality of parameters which modulates it. | ||
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== Applications == | == Applications == | ||
