Sandbox Reserved 1654: Difference between revisions
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***2 zinc binding sites, the first one is composed of <scene name='86/868187/Z1/3'>Cys515, Cys518, Cys537, Cys540</scene> and the second is composed of <scene name='86/868187/Z2/2'>Cys527, Cys532, His545 and His553</scene>. | ***2 zinc binding sites, the first one is composed of <scene name='86/868187/Z1/3'>Cys515, Cys518, Cys537, Cys540</scene> and the second is composed of <scene name='86/868187/Z2/2'>Cys527, Cys532, His545 and His553</scene>. | ||
** '''RRMs patterns'''<ref>DOI 10.1101/gad.241133.114</ref> | ** '''RRMs patterns'''<ref>DOI 10.1101/gad.241133.114</ref> | ||
<StructureSection load='2MKK' size='350' side='right' caption='RNA binding to | <StructureSection load='2MKK' size='350' side='right' caption='RNA binding to RRMs' scene=''> | ||
</StructureSection> | </StructureSection> | ||
RRMs are necessary and sufficient for the CPE sequence recognition on RNA. They bind to RNA with high affinity and allow the RNA to take the good position. RRM1 binds to the four first RNA nucleotides (UUUU) and RRM2 binds to the 3' adenine of CPE. The two RRMs take a V-shaped conformation, facing to each other: | RRMs are necessary and sufficient for the CPE sequence recognition on RNA. They bind to RNA with high affinity and allow the RNA to take the good position. RRM1 binds to the four first RNA nucleotides (UUUU) and RRM2 binds to the 3' adenine of CPE. The two RRMs take a V-shaped conformation, facing to each other: | ||
