Sandbox Reserved 1653: Difference between revisions
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==='''CTD and Beam'''=== | ==='''CTD and Beam'''=== | ||
CTD and <scene name='86/868186/Beam_1_couleurs/1'>beams</scene> are intracellular. The beam interacts with the CTD, and both are required for mechanical activation of the channel.<ref name=" | CTD and <scene name='86/868186/Beam_1_couleurs/1'>beams</scene> are intracellular. The beam interacts with the CTD, and both are required for mechanical activation of the channel.<ref name="Architecture"/> | ||
The <scene name='86/868186/Ctd_trimeric/1'>CTD</scene> is a trimeric structure and is a part of the pore module of Piezo1 channel. The CTD interacts with the long <scene name='86/868186/Anchor/1'>anchorα</scene>, and forms a hydrophobic interface. This forms a tripartite interaction with the <scene name='86/868186/E_dans_ctd/1'>glutamate-rich regions of the CTD</scene>.<ref name="mechanogating"> DOI 10.1038/nature25743 </ref> | The <scene name='86/868186/Ctd_trimeric/1'>CTD</scene> is a trimeric structure and is a part of the pore module of Piezo1 channel. The CTD interacts with the long <scene name='86/868186/Anchor/1'>anchorα</scene>, and forms a hydrophobic interface. This forms a tripartite interaction with the <scene name='86/868186/E_dans_ctd/1'>glutamate-rich regions of the CTD</scene>.<ref name="mechanogating"> DOI 10.1038/nature25743 </ref> | ||
It forms an intracellular vestibule along the z-axis, and it is essential for ion permeation properties.<ref name=" | It forms an intracellular vestibule along the z-axis, and it is essential for ion permeation properties.<ref name="Architecture"> DOI 10.1038/nature15247 </ref> The CTD triangular plane has a beam-facing side of the triangular, and it is separated into two surfaces with negative and positive electrostatic potentials.<ref name="mechanogating"/> | ||
The beam is a 90 Å-long intracellular structure in the central region of the ion channel. It is a <scene name='86/868186/Blade_ans_beam/1'>part of the three-bladed</scene>, propeller-shaped architecture characteristic of Piezo1. It is a piece of the “beam-CTD-anchor-OH-IH” relaying interface that forms the central pore module. It is because the beam connects the THU, to the CTD and the outer helix (OH) that it enables the transmission of the mechanical force, and thus the opening of Piezo1’s pore.<ref name="mechanogating"/> It delivers the mechanical signals from the blades, or the plasma membrane, to the central pore module region.<ref name="structural analysis"> DOI 10.4236/jbm.2019.712012 </ref> | The beam is a 90 Å-long intracellular structure in the central region of the ion channel. It is a <scene name='86/868186/Blade_ans_beam/1'>part of the three-bladed</scene>, propeller-shaped architecture characteristic of Piezo1. It is a piece of the “beam-CTD-anchor-OH-IH” relaying interface that forms the central pore module. It is because the beam connects the THU, to the CTD and the outer helix (OH) that it enables the transmission of the mechanical force, and thus the opening of Piezo1’s pore.<ref name="mechanogating"/> It delivers the mechanical signals from the blades, or the plasma membrane, to the central pore module region.<ref name="structural analysis"> DOI 10.4236/jbm.2019.712012 </ref> | ||
