Sandbox Reserved 1653: Difference between revisions
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Indeed, mPiezo trimer is a non-planar conformation inside lipid bilayer, it produces a local dome-shaped deformation of the membrane. In cells, this membrane curvature project towards the cytoplasm and some electrostatic interactions stabilize the trimeric assembly in its curved conformation.<ref name = "nv article"> DOI 10.7554/eLife.33660</ref> | Indeed, mPiezo trimer is a non-planar conformation inside lipid bilayer, it produces a local dome-shaped deformation of the membrane. In cells, this membrane curvature project towards the cytoplasm and some electrostatic interactions stabilize the trimeric assembly in its curved conformation.<ref name = "nv article"> DOI 10.7554/eLife.33660</ref> | ||
The structure of Piezo1 offers a plausible explanation for the origin of its tension [https://en.wikipedia.org/wiki/Gating_(electrophysiology) gating]. Indeed, if the semi-spherical dome becomes flatter when Piezo1 opens, then the channel membrane system will expand thanks to the flexibility of the blades. | The structure of Piezo1 offers a plausible explanation for the origin of its tension [https://en.wikipedia.org/wiki/Gating_(electrophysiology) gating]. Indeed, if the semi-spherical dome becomes flatter when Piezo1 opens, then the channel membrane system will expand thanks to the flexibility of the blades. | ||
However, because flattening does not constrain the pore to open wide, expansion and pore diameter are decoupled, such that Piezo1 can exhibit its small conductance and cation selectivity, properties that are essential to its function.<ref name ="Piezo Senses Tension"/>,<ref name=" | However, because flattening does not constrain the pore to open wide, expansion and pore diameter are decoupled, such that Piezo1 can exhibit its small conductance and cation selectivity, properties that are essential to its function.<ref name ="Piezo Senses Tension"/>,<ref name="Lin" /> | ||
