Sandbox Reserved 1658: Difference between revisions

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In mature organisms, neuropilins primarily perform the role of pro-angiogenic co-receptors. Neuropilin-1 works as a specific co-receptor of VEGFR-2 for VEGF-A. After binding and activation, neuropilins promote angiogenesis by stabilizing the VEGF/VEGFR binding.

Researchers also think that neuropilins affect the vascular motility of endothelial cells, independently of their action on the protein complex VEGF/VEGFR.

Researchers also think that neuropilins affect the vascular motility of endothelial cells, independently of their action on the protein complex VEGF/VEGFR. Besides, NRP1 enhances the signalling of the extra-cellular matrix in endothelial cells.

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In neuronal tissues, NRP1 associate with semaphoring-3A to perform growth cone guidance. It helps guiding axonal growth during the development of the nervous system by mediating the chemorepulsant activity of semaphorin.

<h5>In the immune system

An expression of NRP1 has been detected in several cells of the immune system such as macrophages, dendritic cells, but also in T cell subsets. In dendritic cells and T cells subsets, NRP1 helps to trigger the immune response. Researchers also think that NRP1 should represent à new activation marker for T cells.

== Disease ==

Sandbox Reserved 1658: Difference between revisions

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@@ Line 29: / Line 29: @@
 <p align="justify">In mature organisms, neuropilins primarily perform the role of pro-angiogenic co-receptors. Neuropilin-1 works as a specific co-receptor of VEGFR-2 for VEGF-A. After binding and activation, neuropilins promote angiogenesis by stabilizing the VEGF/VEGFR binding.
-Researchers also think that neuropilins affect the vascular motility of endothelial cells, independently of their action on the protein complex VEGF/VEGFR.
+Researchers also think that neuropilins affect the vascular motility of endothelial cells, independently of their action on the protein complex VEGF/VEGFR. Besides, NRP1 enhances the signalling of the extra-cellular matrix in endothelial cells.
 </p>
@@ Line 35: / Line 35: @@
 <p align="justify">In neuronal tissues, NRP1 associate with semaphoring-3A to perform growth cone guidance. It helps guiding axonal growth during the development of the nervous system by mediating the chemorepulsant activity of semaphorin.</p>
+<h5>In the immune system</p>
+An expression of NRP1 has been detected in several cells of the immune system such as macrophages, dendritic cells, but also in T cell subsets. In dendritic cells and T cells subsets, NRP1 helps to trigger the immune response. Researchers also think that NRP1 should represent à new activation marker for T cells.
 == Disease ==