Sandbox Reserved 1661: Difference between revisions
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You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID:21638687</ref> to the rescue. | You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID:21638687</ref> to the rescue. | ||
== | == Somatotropin and Genetic origin == | ||
Somatotropin is a polypeptide hormone produced by the somatotropic cells of the pituitary gland. Growth hormone, a protein circulating in the blood. | |||
The Human Growth Hormone has its origin on chromosome 17. There it gets encoded by the Growth hormone 1 gene along with four other related genes. Three of these genes are encoding human chorionic somatomammotropin, which is closely related to somatotropin. They are all in the same transcriptional orientation. | |||
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== Functions == | |||
Somatropin plays an important role in physiological environments such as: increasing muscle mass, reducing fat mass, providing the energy necessary for tissue growth, maintaining the right level of glucose and lipids ... and the development of the individual's body <ref> <ref name="ncbi> Southern Reh, C. and E Geffner, M. (2010), Somatotropin in the treatment of growth hormone defiviency and Tuuner syndrome in pediatric patients: a review. Clin Pharmacol. 2010; 2:11-112. doi: 10.2147/CPAA.S6525. <ref>PMID:22291494</ref> DOI 10.2147/CPAA.S6525</ref> . It acts directly on a cell surface or indirectly <ref name="ncbi" />. In the second case, somatropin stimulates tissues such as the liver, which in turn allows the synthesis and secretion of IGF-1, thus enabling the development of cell growth, tissue, bone and thus the linear growth of the individual <ref> <ref name="britannica"> Utiger, R. D. and other Encyclopedia Britannica Contributors (1998), Insulin-like growth factor. Science, Chemistry.</ref>. | |||
== Relevance == | == Relevance == | ||