Sandbox Reserved 1648: Difference between revisions
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Leptin receptors belong to the family of class 1 cytokine receptors. | Leptin receptors belong to the family of class 1 cytokine receptors. | ||
The leptin receptor protein is a molecule that exists in different forms : short or long. It consists of an extracellular chain of 816 amino acids, a transmembrane domain of 23 amino acids and a cytoplasmic domain. This cytoplasmic domain is made up of 34 amino acids for the short form of the leptin receptor and 303 amino acids for the long form. | |||
The leptin receptor protein is a molecule that exists in different forms : short or long. It consists of an extracellular chain of 816 amino acids, a transmembrane domain of 23 amino acids and a cytoplasmic domain. This cytoplasmic domain is made up of 34 amino acids for the short form of the leptin receptor and 303 amino acids for the long form. | |||
The extracellular part is itself subdivided into 5 functional domains : | The extracellular part is itself subdivided into 5 functional domains : | ||
- distal membrane homology of the first cytokine receptor (CRH1) | - distal membrane homology of the first cytokine receptor (CRH1) | ||
- immunoglobulin (Ig) domain | - immunoglobulin (Ig) domain | ||
- second homology of the cytokine receptor (CRH2) | - second homology of the cytokine receptor (CRH2) | ||
- two membrane proximal fibronectine type-III (FNIII) domains | - two membrane proximal fibronectine type-III (FNIII) domains | ||
