Sandbox Reserved 1644: Difference between revisions
From Proteopedia
Jump to navigationJump to search
No edit summary |
No edit summary |
||
| Line 10: | Line 10: | ||
<br> | <br> | ||
== Function == | == Function == | ||
< | |||
The mitochondrial Lon protease is an important regulator of mitochondrial [https://en.wikipedia.org/wiki/Metabolism metabolism] including the maintenance and repair of mitochondrial [https://en.wikipedia.org/wiki/DNA DNA]. This protein is also essential for homeostasis of mitochondria, and by regulating some regulatory proteins which have a short life or damaged proteins. | <p align="justify">The mitochondrial Lon protease is an important regulator of mitochondrial [https://en.wikipedia.org/wiki/Metabolism metabolism] including the maintenance and repair of mitochondrial [https://en.wikipedia.org/wiki/DNA DNA]. This protein is also essential for homeostasis of mitochondria, and by regulating some regulatory proteins which have a short life or damaged proteins. | ||
<br> | <br> | ||
Lon protease has three main roles. | Lon protease has three main roles. | ||
This protein is able to do a '''[https://en.wikipedia.org/wiki/Proteolysis proteolytic] digestion''' of oxidized proteins which allows the renewal of essential mitochondrial enzymes such as [https://en.wikipedia.org/wiki/Aconitase aconitase] or [https://en.wikipedia.org/wiki/TFAM Mitochondrial transcription factor A]. | This protein is able to do a '''[https://en.wikipedia.org/wiki/Proteolysis proteolytic] digestion''' of oxidized proteins which allows the renewal of essential mitochondrial enzymes such as [https://en.wikipedia.org/wiki/Aconitase aconitase] or [https://en.wikipedia.org/wiki/TFAM Mitochondrial transcription factor A]. | ||
Lon protease is involved in [https://en.wikipedia.org/wiki/Mitochondrial_DNA mtDNA] [https://en.wikipedia.org/wiki/DNA_replication replication] and [https://en.wikipedia.org/w/index.php?title=Mitogenesis&redirect=no mitogenesis] by being a '''mitochondrial [https://en.wikipedia.org/wiki/DNA-binding_protein DNA-bing protein]'''. | Lon protease is involved in [https://en.wikipedia.org/wiki/Mitochondrial_DNA mtDNA] [https://en.wikipedia.org/wiki/DNA_replication replication] and [https://en.wikipedia.org/w/index.php?title=Mitogenesis&redirect=no mitogenesis] by being a '''mitochondrial [https://en.wikipedia.org/wiki/DNA-binding_protein DNA-bing protein]'''. Human Lon and mtDNA associate at the level of their 4 contiguous [https://en.wikipedia.org/wiki/Guanine guanine] sequence and form a [https://en.wikipedia.org/wiki/G-quadruplex G-quadruplex]<ref>Bota, Daniela A., and Kelvin J. A. Davies. “Mitochondrial Lon Protease in Human Disease and Aging: Including an Etiologic Classification of Lon-Related Diseases and Disorders.” Free Radical Biology & Medicine 100 (November 2016): 188–98. https://doi.org/10.1016/j.freeradbiomed.2016.06.031.</ref>. | ||
Mitochondrial Lon protease interacts with [https://en.wikipedia.org/wiki/Chaperone_(protein) protein chaperone], notably [https://en.wikipedia.org/wiki/Chaperonin HSP60]-[https://en.wikipedia.org/wiki/Hsp70 Hsp70] complex to protect cell from apoptosis under environmental stress<ref>Bota, Daniela A., and Kelvin J. A. Davies. “Mitochondrial Lon Protease in Human Disease and Aging: Including an Etiologic Classification of Lon-Related Diseases and Disorders.” Free Radical Biology & Medicine 100 (November 2016): 188–98. https://doi.org/10.1016/j.freeradbiomed.2016.06.031.</ref>. | Mitochondrial Lon protease interacts with [https://en.wikipedia.org/wiki/Chaperone_(protein) protein chaperone], notably [https://en.wikipedia.org/wiki/Chaperonin HSP60]-[https://en.wikipedia.org/wiki/Hsp70 Hsp70] complex to protect cell from apoptosis under environmental stress<ref>Bota, Daniela A., and Kelvin J. A. Davies. “Mitochondrial Lon Protease in Human Disease and Aging: Including an Etiologic Classification of Lon-Related Diseases and Disorders.” Free Radical Biology & Medicine 100 (November 2016): 188–98. https://doi.org/10.1016/j.freeradbiomed.2016.06.031.</ref>. | ||
<br> | <br> | ||
