Sandbox Reserved 1648: Difference between revisions
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== '''Activation''' == | == '''Activation''' == | ||
The activation of the leptin receptor is done through the CRH2, IGD and FN III domains. | The activation of the leptin receptor is done through the CRH2, IGD and FN III domains. | ||
The CRH2 domain is the main leptin binding site on the receptor. This domain is required for the activation of the receptor. It is composed of a region of four consecutive hydrophobic residues. | The CRH2 domain is the main leptin binding site on the receptor. This domain is required for the activation of the receptor. It is composed of a region of four consecutive hydrophobic residues. | ||
The IGD domain has no affinity for leptin but is nevertheless required for receptor activation. In the absence of this domain, the result is a receptor with a wild-type affinity for leptin, but completely devoid of biological activity. | The IGD domain has no affinity for leptin but is nevertheless required for receptor activation. In the absence of this domain, the result is a receptor with a wild-type affinity for leptin, but completely devoid of biological activity. | ||
In the FN III domains, there are two conserved cysteines that are crucial for the activation of the receptor. | In the FN III domains, there are two conserved cysteines that are crucial for the activation of the receptor. | ||
In contrast, the receptor functionality is hardly affected when the CRH1 domain is deleted. | In contrast, the receptor functionality is hardly affected when the CRH1 domain is deleted. | ||
