Sandbox Reserved 1644: Difference between revisions
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Mammalian Lon protein only interacts with single-stranded DNA (ssDNA) but not dsDNA. There are therefore special sequences for interaction with G-rich DNA as well as RNA. In addition, the binding of a substrate to the protein stimulates the interaction with the DNA. | Mammalian Lon protein only interacts with single-stranded DNA (ssDNA) but not dsDNA. There are therefore special sequences for interaction with G-rich DNA as well as RNA. In addition, the binding of a substrate to the protein stimulates the interaction with the DNA. | ||
[https://en.wikipedia.org/wiki/Mitochondrial_DNA mtDNA] binds to the Lon protein with different affinities depending on the state of the cell and the type of cell meeting the following four parameters: | [https://en.wikipedia.org/wiki/Mitochondrial_DNA mtDNA] binds to the Lon protein with different affinities depending on the state of the cell and the type of cell meeting the following four parameters: | ||
<br> | |||
- the single stranding state of mtDNA | - the single stranding state of mtDNA | ||
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- the bioavailability of the mtDNA binding sites | - the bioavailability of the mtDNA binding sites | ||
<br> | |||
- the affinity of the protein for a given DNA sequence | - the affinity of the protein for a given DNA sequence | ||
<br> | |||
- the total number of high and low affinity Lon binding sites present</p> | - the total number of high and low affinity Lon binding sites present</p> | ||
