Sandbox Reserved 1648: Difference between revisions

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== '''Signaling pathways''' ==

The leptin receptor has [https://en.wikipedia.org/wiki/Cytokine_receptor cytokine receptor] characteristics. The transduction of the signal by this type of receptor involves the formation of multimeric complexes. This leads to the recruitment of tyrosine kinases, in particular those of the JAK family, which will phosphorylate [https://en.wikipedia.org/wiki/STAT_protein#:~:text=Members%20of%20the%20signal%20transducer,associated%20Janus%20kinases%20(JAK) STAT-like transcription factors] at the cytoplasmic tail of the receptor. Recruitment and activation of secondary signalling molecules enable the leptin receptor signalling via the [https://en.wikipedia.org/wiki/MAPK/ERK_pathway MAPK],[https://www.cellsignal.com/pathways/ampk-signaling-pathway AMPK], [https://en.wikipedia.org/wiki/PI3K/AKT/mTOR_pathway PI3K and mTOR] pathways.

The leptin receptor has [https://en.wikipedia.org/wiki/Cytokine_receptor cytokine receptor] characteristics. The transduction of the signal by this type of receptor involves the formation of multimeric complexes. This leads to the recruitment of tyrosine kinases, in particular those of the [https://en.wikipedia.org/wiki/Janus_kinase JAK] family, which will phosphorylate [https://en.wikipedia.org/wiki/STAT_protein#:~:text=Members%20of%20the%20signal%20transducer,associated%20Janus%20kinases%20(JAK) STAT-like transcription factors] at the cytoplasmic tail of the receptor. Recruitment and activation of secondary signalling molecules enable the leptin receptor signalling via the [https://en.wikipedia.org/wiki/MAPK/ERK_pathway MAPK],[https://www.cellsignal.com/pathways/ampk-signaling-pathway AMPK], [https://en.wikipedia.org/wiki/PI3K/AKT/mTOR_pathway PI3K and mTOR] pathways.

Sandbox Reserved 1648: Difference between revisions

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Revision as of 18:49, 13 January 2021 view source Léane Costa-Roch (talk \| contribs) 67 edits No edit summary ← Older edit		Revision as of 18:56, 13 January 2021 view source Léane Costa-Roch (talk \| contribs) 67 edits No edit summary Newer edit →
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	== '''Signaling pathways''' ==		== '''Signaling pathways''' ==
	The leptin receptor has [https://en.wikipedia.org/wiki/Cytokine_receptor cytokine receptor] characteristics. The transduction of the signal by this type of receptor involves the formation of multimeric complexes. This leads to the recruitment of tyrosine kinases, in particular those of the JAK family, which will phosphorylate [https://en.wikipedia.org/wiki/STAT_protein#:~:text=Members%20of%20the%20signal%20transducer,associated%20Janus%20kinases%20(JAK) STAT-like transcription factors] at the cytoplasmic tail of the receptor. Recruitment and activation of secondary signalling molecules enable the leptin receptor signalling via the [https://en.wikipedia.org/wiki/MAPK/ERK_pathway MAPK],[https://www.cellsignal.com/pathways/ampk-signaling-pathway AMPK], [https://en.wikipedia.org/wiki/PI3K/AKT/mTOR_pathway PI3K and mTOR] pathways.		The leptin receptor has [https://en.wikipedia.org/wiki/Cytokine_receptor cytokine receptor] characteristics. The transduction of the signal by this type of receptor involves the formation of multimeric complexes. This leads to the recruitment of tyrosine kinases, in particular those of the [https://en.wikipedia.org/wiki/Janus_kinase JAK] family, which will phosphorylate [https://en.wikipedia.org/wiki/STAT_protein#:~:text=Members%20of%20the%20signal%20transducer,associated%20Janus%20kinases%20(JAK) STAT-like transcription factors] at the cytoplasmic tail of the receptor. Recruitment and activation of secondary signalling molecules enable the leptin receptor signalling via the [https://en.wikipedia.org/wiki/MAPK/ERK_pathway MAPK],[https://www.cellsignal.com/pathways/ampk-signaling-pathway AMPK], [https://en.wikipedia.org/wiki/PI3K/AKT/mTOR_pathway PI3K and mTOR] pathways.