Sandbox Reserved 1654: Difference between revisions

***<scene name='86/868187/Rmm/1'>Trp331</scene> positions RRM2 relative to RRM1 by inserting between the beta sheet and <scene name='86/868187/Rmm/9'>alpha1 helix</scene> of RRM2.  

***After the helical turn, the interdomain linker folds in a <scene name='86/868187/Rmm/11'>beta strand</scene> which is anti-parallel to the <scene name='86/868187/Rmm/12'>beta2 strand</scene> (RRM2). The interdomain linker is therefore a kind of joint for the relative orientation of the two RRMs.

The N-terminal region of CPEB includes residues in the fourth β strand of the RRM2 domain. Within the linker region between RRM2 and ZZ domains, Leu510 shows long-range interactions with the aromatic ring of Tyr535 in the β2 strand, suggesting that there may be a close interaction between these two domains of CPEB meaning a close interaction between RRM2 and ZZ domains. Disruption of the CPEB-ZZ domain structure could affect the stability of the RRM2 domain structure through loss of the interdomain interface.

== Function ==