Sandbox Reserved 1648: Difference between revisions
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The activation of the leptin receptor <ref> Leptin receptor : https://en.wikipedia.org/wiki/Leptin_receptor </ref>is done through the '''CRH2, IGD and FN III''' domains <ref>PMID:28270795</ref>. | The activation of the leptin receptor <ref> Leptin receptor : https://en.wikipedia.org/wiki/Leptin_receptor </ref>is done through the '''CRH2, IGD and FN III''' domains <ref>PMID:28270795</ref>. | ||
The '''CRH2''' domain is the main leptin binding site on the receptor. This domain is required for the activation of the receptor. It is composed of a region of four consecutive hydrophobic residues. | The '''CRH2''' domain is the main leptin binding site on the receptor. This domain is required for the activation of the receptor. It is composed of a region of four consecutive hydrophobic residues. In particular, Leu13 and Leu86 of leptin interact with Leu 504 in CRH2 forming a bond via hydrophobic interactions<ref>PMID: 15923664</ref>. | ||
The '''IGD''' domain has no affinity for leptin but is nevertheless required for receptor activation. In the absence of this domain, the result is a receptor with a wild-type affinity for leptin. However, the receptor is completely devoid of biological activity. | The '''IGD''' domain has no affinity for leptin but is nevertheless required for receptor activation. In the absence of this domain, the result is a receptor with a wild-type affinity for leptin. However, the receptor is completely devoid of biological activity. | ||
