Sandbox Reserved 1648: Difference between revisions

Line 50:

The activation of the leptin receptor <ref> Leptin receptor : https://en.wikipedia.org/wiki/Leptin_receptor </ref>is done through the '''CRH2, IGD and FN III''' domains <ref>PMID:28270795</ref>.

The '''CRH2''' domain is the main leptin binding site on the receptor. This domain is required for the activation of the receptor. It is composed of a region of four consecutive hydrophobic residues. In particular, Leu13 and Leu86 of leptin interact with Leu 504 in CRH2 forming a bond via hydrophobic interactions<ref>PMID: 15923664</ref>.

The '''CRH2''' domain is the main leptin binding site on the receptor. This domain is required for the activation of the receptor. It is composed of a region of four consecutive hydrophobic residues. In particular, '''Leu13''' and '''Leu86''' of leptin interact with '''Leu 504''' in CRH2 forming a bond via hydrophobic interactions<ref>PMID: 15923664</ref>.

The '''IGD''' domain has no affinity for leptin but is nevertheless required for receptor activation. In the absence of this domain, the result is a receptor with a wild-type affinity for leptin. However, the receptor is completely devoid of biological activity.

The '''IGD''' domain has no affinity for leptin but is nevertheless '''required''' for receptor activation. In the absence of this domain, the result is a receptor with a wild-type affinity for leptin. However, the receptor is completely devoid of biological activity.

In the '''FN III''' domains, there are two conserved '''cysteines''' ('''Cys-672 and Cys-751''' <ref>PMID: 15840566</ref>) that are crucial for the activation of the receptor.

Sandbox Reserved 1648: Difference between revisions

Navigation menu

Page actions

Page actions

Personal tools

Navigation

Search

Tools

@@ Line 50: / Line 50: @@
 The activation of the leptin receptor <ref> Leptin receptor : https://en.wikipedia.org/wiki/Leptin_receptor </ref>is done through the '''CRH2, IGD and FN III''' domains <ref>PMID:28270795</ref>.
-The '''CRH2''' domain is the main leptin binding site on the receptor. This domain is required for the activation of the receptor. It is composed of a region of four consecutive hydrophobic residues. In particular, Leu13 and Leu86 of leptin interact with Leu 504 in CRH2 forming a bond via hydrophobic interactions<ref>PMID: 15923664</ref>.
+The '''CRH2''' domain is the main leptin binding site on the receptor. This domain is required for the activation of the receptor. It is composed of a region of four consecutive hydrophobic residues. In particular, '''Leu13''' and '''Leu86''' of leptin interact with '''Leu 504''' in CRH2 forming a bond via hydrophobic interactions<ref>PMID: 15923664</ref>.
-The '''IGD''' domain has no affinity for leptin but is nevertheless required for receptor activation. In the absence of this domain, the result is a receptor with a wild-type affinity for leptin. However, the receptor is completely devoid of biological activity.
+The '''IGD''' domain has no affinity for leptin but is nevertheless '''required''' for receptor activation. In the absence of this domain, the result is a receptor with a wild-type affinity for leptin. However, the receptor is completely devoid of biological activity.
 In the '''FN III''' domains, there are two conserved '''cysteines''' ('''Cys-672 and Cys-751''' <ref>PMID: 15840566</ref>) that are crucial for the activation of the receptor.