Sandbox Reserved 1660: Difference between revisions

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The presentation of many of ligands can have immunopotentiating effects, such as serving as an adjuvant against [https://en.wikipedia.org/wiki/Malaria malaria] or resulting in a more rapid clearance of certain [https://en.wikipedia.org/wiki/Virus virus] infections. They can also be protective in autoimmune diseases or cancer<ref name="Immunity"/><ref>Sköld, M.; Behar, S. M. Role of CD1d-Restricted NKT Cells in Microbial Immunity. Infect Immun 2003, 71 (10), 5447–5455. https://doi.org/10.1128/IAI.71.10.5447-5455.2003.</ref~~><ref name="affinity"/~~>.

The presentation of many of ligands can have immunopotentiating effects, such as serving as an adjuvant against [https://en.wikipedia.org/wiki/Malaria malaria] or resulting in a more rapid clearance of certain [https://en.wikipedia.org/wiki/Virus virus] infections. They can also be protective in autoimmune diseases or cancer<ref name="affinity"/><ref name="Immunity"/><ref>Sköld, M.; Behar, S. M. Role of CD1d-Restricted NKT Cells in Microbial Immunity. Infect Immun 2003, 71 (10), 5447–5455. https://doi.org/10.1128/IAI.71.10.5447-5455.2003.</ref>.

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The presence of high amount of CD1d proteins on the cell surface of NKT cells gives rise to a novel type of NKT cells. This larger amount of CD1d proteins allows the Cd1d high NKT cells to bind more alpha-galactosylceramide molecules and therefore to can produce greater levels of interleukin-4 and INF-gamma molecules leading to possible therapeutical effects<ref~~>Rossjohn, J., Pellicci, D. G., Patel, O., Gapin, L., & Godfrey, D. I. (2012). Recognition of CD1d-restricted antigens by natural killer T cells. Nature reviews. Immunology, 12(12), 845–857. https:~~/~~/doi.org/10.1038/nri3328.</ref~~>.

The presence of high amount of CD1d proteins on the cell surface of NKT cells gives rise to a novel type of NKT cells. This larger amount of CD1d proteins allows the Cd1d high NKT cells to bind more alpha-galactosylceramide molecules and therefore to can produce greater levels of interleukin-4 and INF-gamma molecules leading to possible therapeutical effects<ref name="affinity"/>.

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Sandbox Reserved 1660: Difference between revisions

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-The presentation of many of ligands can have immunopotentiating effects, such as serving as an adjuvant against [https://en.wikipedia.org/wiki/Malaria malaria] or resulting in a more rapid clearance of certain [https://en.wikipedia.org/wiki/Virus virus] infections. They can also be protective in autoimmune diseases or cancer<ref name="Immunity"/><ref>Sköld, M.; Behar, S. M. Role of CD1d-Restricted NKT Cells in Microbial Immunity. Infect Immun 2003, 71 (10), 5447–5455. https://doi.org/10.1128/IAI.71.10.5447-5455.2003.</ref><ref name="affinity"/>.
+The presentation of many of ligands can have immunopotentiating effects, such as serving as an adjuvant against [https://en.wikipedia.org/wiki/Malaria malaria] or resulting in a more rapid clearance of certain [https://en.wikipedia.org/wiki/Virus virus] infections. They can also be protective in autoimmune diseases or cancer<ref name="affinity"/><ref name="Immunity"/><ref>Sköld, M.; Behar, S. M. Role of CD1d-Restricted NKT Cells in Microbial Immunity. Infect Immun 2003, 71 (10), 5447–5455. https://doi.org/10.1128/IAI.71.10.5447-5455.2003.</ref>.
 </p>
 <p align="justify">
-The presence of high amount of CD1d proteins on the cell surface of NKT cells gives rise to a novel type of NKT cells. This larger amount of CD1d proteins allows the Cd1d high NKT cells to bind more alpha-galactosylceramide molecules and therefore to can produce greater levels of interleukin-4 and INF-gamma molecules leading to possible therapeutical effects<ref>Rossjohn, J., Pellicci, D. G., Patel, O., Gapin, L., & Godfrey, D. I. (2012). Recognition of CD1d-restricted antigens by natural killer T cells. Nature reviews. Immunology, 12(12), 845–857. https://doi.org/10.1038/nri3328.</ref>.
+The presence of high amount of CD1d proteins on the cell surface of NKT cells gives rise to a novel type of NKT cells. This larger amount of CD1d proteins allows the Cd1d high NKT cells to bind more alpha-galactosylceramide molecules and therefore to can produce greater levels of interleukin-4 and INF-gamma molecules leading to possible therapeutical effects<ref name="affinity"/>.
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