Sandbox Reserved 1657: Difference between revisions
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{{5CZX}}<!-- PLEASE ADD YOUR CONTENT BELOW HERE --> | |||
==5CZX== | ==5CZX== | ||
<StructureSection load=' | <StructureSection load='' size='360' side='right' caption='Crystal structure of Notch3 NRR in complex with 20358 Fab' scene=''> | ||
The neurogenic locus notch homolog protein 3 is a protein encoded by the [https://en.wikipedia.org/wiki/Notch_3 NOTCH3 gene]. There are 4 [https://en.wikipedia.org/wiki/Notch_signaling_pathway notch receptors] in [https://en.wikipedia.org/wiki/Mammal mammals], all of which are transmembrane proteins and notch signalling regulates a very diverse set of biological functions; The most commun is the [https://en.wikipedia.org/wiki/Cell_lineage#:~:text=Cell%20lineage%20denotes%20the%20developmental,that%20can%20no%20longer%20divide. cell lineage determination]. Therefore, changes in the activity of these receptors is associated with various benign and malignant diseases as [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6142501/ T-ALL (T-lineage acute lymphoblastic leukemia)]. T-ALL is characterized by the uncontrolled proliferation of T-cell [https://en.wikipedia.org/wiki/Lymphoblast lymphoblasts] in the blood, the brown marrow and the tissues. | The neurogenic locus notch homolog protein 3 is a protein encoded by the [https://en.wikipedia.org/wiki/Notch_3 NOTCH3 gene]. There are 4 [https://en.wikipedia.org/wiki/Notch_signaling_pathway notch receptors] in [https://en.wikipedia.org/wiki/Mammal mammals], all of which are transmembrane proteins and notch signalling regulates a very diverse set of biological functions; The most commun is the [https://en.wikipedia.org/wiki/Cell_lineage#:~:text=Cell%20lineage%20denotes%20the%20developmental,that%20can%20no%20longer%20divide. cell lineage determination]. Therefore, changes in the activity of these receptors is associated with various benign and malignant diseases as [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6142501/ T-ALL (T-lineage acute lymphoblastic leukemia)]. T-ALL is characterized by the uncontrolled proliferation of T-cell [https://en.wikipedia.org/wiki/Lymphoblast lymphoblasts] in the blood, the brown marrow and the tissues. | ||
