Sandbox reserved 1651: Difference between revisions
From Proteopedia
Jump to navigationJump to search
Fabian Kunz (talk | contribs) No edit summary |
Fabian Kunz (talk | contribs) No edit summary |
||
| Line 2: | Line 2: | ||
<StructureSection load='6Z1N' size='360' side='right' caption='Caption for this structure' scene=''> | <StructureSection load='6Z1N' size='360' side='right' caption='Caption for this structure' scene=''> | ||
Cis-Prenyltransferases (cis-PTs) is a large enzyme family which is well conserved in all domains of life. Cis-PTs catalyze condensation reactions of [https://en.wikipedia.org/wiki/Isopentenyl_pyrophosphate isopentenyl pyrophosphate (IPP)] and produce linear polyprenyl diphosphate. The length of this [https://en.wikipedia.org/wiki/Terpenoid isoprenoid] carbon chain varies from short molecules like [https://en.wikipedia.org/wiki/Geranyl_pyrophosphate geranyl diphosphate] (C10) to natural rubber (C>10’000). The human cis-Prenyltransferase Complex (hcis-PT) has an essential role in protein [https://en.wikipedia.org/wiki/N-linked_glycosylation N-glycosylation]. It synthesises the precursor of glycosyl carrier [https://en.wikipedia.org/wiki/Dolichol dolichol]-phosphate. Mutations in genes coding for hcis-PT can cause severe diseases, such as [https://en.wikipedia.org/wiki/Retinitis_pigmentosa retinitis pigmentosa]. | Cis-Prenyltransferases (cis-PTs) is a large enzyme family which is well conserved in all domains of life. Cis-PTs catalyze condensation reactions of [https://en.wikipedia.org/wiki/Isopentenyl_pyrophosphate isopentenyl pyrophosphate (IPP)] and produce linear polyprenyl diphosphate. The length of this [https://en.wikipedia.org/wiki/Terpenoid isoprenoid] carbon chain varies from short molecules like [https://en.wikipedia.org/wiki/Geranyl_pyrophosphate geranyl diphosphate] (C10) to natural rubber (C>10’000). The human cis-Prenyltransferase Complex (hcis-PT) has an essential role in protein [https://en.wikipedia.org/wiki/N-linked_glycosylation N-glycosylation]. It synthesises the precursor of glycosyl carrier [https://en.wikipedia.org/wiki/Dolichol dolichol]-phosphate. Mutations in genes coding for hcis-PT can cause severe diseases, such as [https://en.wikipedia.org/wiki/Retinitis_pigmentosa retinitis pigmentosa].[1] | ||
== Structure == | == Structure == | ||
| Line 46: | Line 46: | ||
<references/> | <references/> | ||
Dyonne T Hartong et al. « Retinitis Pigmentosa ». ''The Lancet''. 18;368(9549):1795‑809, (2006) | |||
[1] Michal Lisnyansky Bar-El et al. «Structural basis of heterotetrameric assembly and disease mutations in the human cis-prenyltransferase ». ''Nature Communications''. '''11''':523, (2020). | |||
[2 ]Dyonne T Hartong et al. « Retinitis Pigmentosa ». ''The Lancet''. 18;368(9549):1795‑809, (2006) | |||
