Sandbox Reserved 1658: Difference between revisions

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<p align="justify">In 2007, a study has demonstrated that the interactions between b1 and b2, and between a2 and (b1/b2) are the same for Neuropilin 1 and 2. However a1 interacts differently with the other domains and these interactions are still not really understood.

The a1 and a2 domains are CUB domains and include <scene name='86/868191/Calcium_binding_site/1'>Calcium binding site</scene><ref name="structural study"/>. The ion is coordinated by two carbonyl oxygens from Ala(252)and Ile(253) and by three negatively charged side chains (Glu(195),Asp(209) and Asp(250))<ref name="structural study"/>.

On an other side, b1 and b2 form a jellyroll<ref name="structural study"/> <scene name='86/868191/Beta_barrel/1'>beta-barrel</scene> composes of 8 beta-sheets (<scene name='86/868191/~~Barrel_general~~/1'>290-294 (violet), 325-330 (green), 334-342 (red), 354-363 (blue), 381-384 (orange),391-395 (cyan),399-411 (brown),418-423 (white)</scene>)~~<ref name="human neuropilin"/>~~.One part of the domain contains three loops that typically constitute the ligand binding site for discoidin family members.</p>

On an other side, b1 and b2 form a jellyroll<ref name="structural study"/> <scene name='86/868191/Beta_barrel/1'>beta-barrel</scene> composes of 8 beta-sheets (<scene name='86/868191/Fin/1'>290-294 (violet), 325-330 (green), 334-342 (red), 354-363 (blue), 381-384 (orange),391-395 (cyan),399-411 (brown),418-423 (white)</scene>).One part of the domain contains three loops that typically constitute the ligand binding site for discoidin family members.</p>

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 <p align="justify">In 2007, a study has demonstrated that the interactions between b1 and b2, and between a2 and (b1/b2) are the same for Neuropilin 1 and 2. However a1 interacts differently with the other domains and these interactions are still not really understood.
 The a1 and a2 domains are CUB domains and include <scene name='86/868191/Calcium_binding_site/1'>Calcium binding site</scene><ref name="structural study"/>. The ion is coordinated by two carbonyl oxygens from Ala(252)and Ile(253) and by three negatively charged side chains (Glu(195),Asp(209) and Asp(250))<ref name="structural study"/>.
-On an other side, b1 and b2 form a jellyroll<ref name="structural study"/> <scene name='86/868191/Beta_barrel/1'>beta-barrel</scene> composes of 8 beta-sheets (<scene name='86/868191/Barrel_general/1'>290-294 (violet), 325-330 (green), 334-342 (red), 354-363 (blue), 381-384 (orange),391-395 (cyan),399-411 (brown),418-423 (white)</scene>)<ref name="human neuropilin"/>.One part of the domain contains three loops that typically constitute the ligand binding site for discoidin family members.</p>
+On an other side, b1 and b2 form a jellyroll<ref name="structural study"/> <scene name='86/868191/Beta_barrel/1'>beta-barrel</scene> composes of 8 beta-sheets (<scene name='86/868191/Fin/1'>290-294 (violet), 325-330 (green), 334-342 (red), 354-363 (blue), 381-384 (orange),391-395 (cyan),399-411 (brown),418-423 (white)</scene>).One part of the domain contains three loops that typically constitute the ligand binding site for discoidin family members.</p>
 == Function ==