Sandbox Reserved 1647: Difference between revisions

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[[Image:TBET.jpg]]

Here, we show that T-bet acts through enhancers to allow the recruitment of Mediator and P-TEFb in the formation of the super elongation complex (SEC). Th1 genes are occupied by RNA polymerase II ~~in Thp cells, while T-bet-mediated recruitment of P-TEFb~~ [[https://proteopedia.org/wiki/index.php/~~3mi9~~]] and mediator ~~[[https://proteopedia.org/wiki/index.php/Mediator]]~~and activates transcriptional elongation giving place to an increased differentiation of Thp into Th1.

Here, we show that T-bet acts through enhancers to allow the recruitment of Mediator[[https://proteopedia.org/wiki/index.php/Mediator]] and P-TEFb[[https://proteopedia.org/wiki/index.php/3mi9]] in the formation of the super elongation complex (SEC). Th1 genes are occupied by RNA polymerase II[[https://proteopedia.org/wiki/index.php/RNA_Polymerase_II]] in Thp cells, while T-bet-mediated recruitment of P-TEFb and mediator and activates transcriptional elongation giving place to an increased differentiation of Thp into Th1.

T-bet can also regulates Th1 cell differentiation by directly initiating gamma interferon (IFN-γ[[https://proteopedia.org/wiki/index.php/6f1e]]) transcription and by suppressing Th2-specific transcription factor GATA-3 [[https://proteopedia.org/wiki/index.php/3dfx]]. The T-bet induced expression of IFN-γ derives Th precursor cells to differentiate into Th1 effector cells.

Sandbox Reserved 1647: Difference between revisions

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@@ Line 31: / Line 31: @@
 [[Image:TBET.jpg]]
-Here, we show that T-bet acts through enhancers to allow the recruitment of Mediator and P-TEFb in the formation of the super elongation complex (SEC). Th1 genes are occupied by RNA polymerase II in Thp cells, while T-bet-mediated recruitment of P-TEFb [[https://proteopedia.org/wiki/index.php/3mi9]] and mediator [[https://proteopedia.org/wiki/index.php/Mediator]]and activates transcriptional elongation giving place to an increased differentiation of Thp into Th1.
+Here, we show that T-bet acts through enhancers to allow the recruitment of Mediator[[https://proteopedia.org/wiki/index.php/Mediator]] and P-TEFb[[https://proteopedia.org/wiki/index.php/3mi9]] in the formation of the super elongation complex (SEC). Th1 genes are occupied by RNA polymerase II[[https://proteopedia.org/wiki/index.php/RNA_Polymerase_II]] in Thp cells, while T-bet-mediated recruitment of P-TEFb and mediator and activates transcriptional elongation giving place to an increased differentiation of Thp into Th1.
 T-bet can also regulates Th1 cell differentiation by directly initiating gamma interferon (IFN-γ[[https://proteopedia.org/wiki/index.php/6f1e]]) transcription and by suppressing Th2-specific transcription factor GATA-3 [[https://proteopedia.org/wiki/index.php/3dfx]]. The T-bet induced expression of IFN-γ derives Th precursor cells to differentiate into Th1 effector cells.