1zel: Difference between revisions

Revision as of 06:38, 26 October 2022

Crystal structure of RV2827C protein from Mycobacterium tuberculosis

Structural highlights

1zel is a 2 chain structure with sequence from Mycobacterium tuberculosis H37Rv. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:	ACT, FMT, MPD, NA
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT, TOPSAN

Function

Q7D6H9_MYCTO

Publication Abstract from PubMed

Tuberculosis (TB) is a major global health threat caused by Mycobacterium tuberculosis (Mtb). It is further fueled by the HIV pandemic and by increasing incidences of multidrug resistant Mtb-strains. Rv2827c, a hypothetical protein from Mtb, has been implicated in the survival of Mtb in the macrophages of the host. The three-dimensional structure of Rv2827c has been determined by the three-wavelength anomalous diffraction technique using bromide-derivatized crystals and refined to a resolution of 1.93 A. The asymmetric unit of the orthorhombic crystals contains two independent protein molecules related by a non-crystallographic translation. The tertiary structure of Rv2827c comprises two domains: an N-terminal domain displaying a winged helix topology and a C-terminal domain, which appears to constitute a new and unique fold. Based on structural homology considerations and additional biochemical evidence, it could be established that Rv2827c is a DNA-binding protein. Once the understanding of the structure-function relationship of Rv2827c extends to the function of Rv2827c in vivo, new clues for the rational design of novel intervention strategies may be obtained.

Structural analysis reveals DNA binding properties of Rv2827c, a hypothetical protein from Mycobacterium tuberculosis.,Janowski R, Panjikar S, Eddine AN, Kaufmann SH, Weiss MS J Struct Funct Genomics. 2009 Apr;10(2):137-50. Epub 2009 Jan 31. PMID:19184528^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Janowski R, Panjikar S, Eddine AN, Kaufmann SH, Weiss MS. Structural analysis reveals DNA binding properties of Rv2827c, a hypothetical protein from Mycobacterium tuberculosis. J Struct Funct Genomics. 2009 Apr;10(2):137-50. Epub 2009 Jan 31. PMID:19184528 doi:10.1007/s10969-009-9060-4

Proteopedia Page Contributors and Editors (what is this?)

OCA

[1] Janowski R, Panjikar S, Eddine AN, Kaufmann SH, Weiss MS. Structural analysis reveals DNA binding properties of Rv2827c, a hypothetical protein from Mycobacterium tuberculosis. J Struct Funct Genomics. 2009 Apr;10(2):137-50. Epub 2009 Jan 31. PMID:19184528 doi:10.1007/s10969-009-9060-4

[1]

@@ Line 3: / Line 3: @@
 <StructureSection load='1zel' size='340' side='right'caption='[[1zel]], [[Resolution|resolution]] 1.93&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[1zel]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Myctu Myctu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZEL OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1ZEL FirstGlance]. <br>
+<table><tr><td colspan='2'>[[1zel]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZEL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ZEL FirstGlance]. <br>
 </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
-<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Rv2827c ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83332 MYCTU])</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1zel FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zel OCA], [https://pdbe.org/1zel PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1zel RCSB], [https://www.ebi.ac.uk/pdbsum/1zel PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1zel ProSAT], [https://www.topsan.org/Proteins/XMTB/1zel TOPSAN]</span></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1zel FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zel OCA], [http://pdbe.org/1zel PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1zel RCSB], [http://www.ebi.ac.uk/pdbsum/1zel PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1zel ProSAT], [http://www.topsan.org/Proteins/XMTB/1zel TOPSAN]</span></td></tr>
 </table>
+== Function ==
+[https://www.uniprot.org/uniprot/Q7D6H9_MYCTO Q7D6H9_MYCTO]
 <div style="background-color:#fffaf0;">
 == Publication Abstract from PubMed ==
@@ Line 22: / Line 23: @@
 </StructureSection>
 [[Category: Large Structures]]
-[[Category: Myctu]]
+[[Category: Mycobacterium tuberculosis H37Rv]]
-[[Category: Janowski, R]]
+[[Category: Janowski R]]
-[[Category: Mueller-dieckmann, J]]
+[[Category: Mueller-dieckmann J]]
-[[Category: Panjikar, S]]
+[[Category: Panjikar S]]
-[[Category: Structural genomic]]
+[[Category: Weiss MS]]
-[[Category: Weiss, M S]]
-[[Category: Auto-rickshaw]]
-[[Category: Helix-turn-helix]]
-[[Category: Hypothetical protein]]
-[[Category: PSI, Protein structure initiative]]
-[[Category: Rv2827c]]
-[[Category: Tbsgc]]
-[[Category: Unknown function]]
-[[Category: Winged-helix]]

1zel: Difference between revisions

Revision as of 06:38, 26 October 2022

Crystal structure of RV2827C protein from Mycobacterium tuberculosis

Structural highlights

Function

Publication Abstract from PubMed

References

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Proteopedia Page Contributors and Editors (what is this?)

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