Sandbox Reserved 1647: Difference between revisions
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This stimulation of IFN-γ can takes place thanks to the action of a nuclear tyrosine kinase, c-Abl. C-Abl induces phosphorylation of T-bet at tyrosine residues <scene name='86/868180/Tyr219/1'>TYR 219</scene>, <scene name='86/868180/Tyr265/1'>TYR 265</scene>, and <scene name='86/868180/Tyr304/1'>TYR 304</scene>. C-Abl phosphorylates the tyrosine residues within the T-box domain, which is the DNA-binding domain of T-bet. This phosphorylation leads to conformational changes of the T-box domain to facilitate the DNA-binding activity of T-bet and appears to play a crucial role in the IFN-γ promoter-binding activity of T-bet. | This stimulation of IFN-γ can takes place thanks to the action of a nuclear tyrosine kinase, c-Abl. C-Abl induces phosphorylation of T-bet at tyrosine residues <scene name='86/868180/Tyr219/1'>TYR 219</scene>, <scene name='86/868180/Tyr265/1'>TYR 265</scene>, and <scene name='86/868180/Tyr304/1'>TYR 304</scene>. C-Abl phosphorylates the tyrosine residues within the T-box domain, which is the DNA-binding domain of T-bet. This phosphorylation leads to conformational changes of the T-box domain to facilitate the DNA-binding activity of T-bet and appears to play a crucial role in the IFN-γ promoter-binding activity of T-bet. | ||
Recently, many studies have reported that T-bet also modulates other Th cell lineages, including Th17, Treg, and follicular Th (TFH) cells, in coordination with many transcription factors, such as the retinoic acid-related orphan receptor-𝛾t (ROR𝛾t)[[https://proteopedia.org/wiki/index.php/6b30]], runt-related transcription factor 3 (RUNX3)[[https://proteopedia.org/wiki/index.php/3mpm]], and B-cell lymphoma-6 (BCL6)[[https://proteopedia.org/wiki/index.php/3lbz]].These findings suggest that T-bet is a transcription factor that is critical for fine-tuning Th cell development. | Recently, many studies have reported that T-bet also modulates other Th cell lineages, including Th17[[https://proteopedia.org/wiki/index.php/6ucg]], Treg, and follicular Th (TFH) cells, in coordination with many transcription factors, such as the retinoic acid-related orphan receptor-𝛾t (ROR𝛾t)[[https://proteopedia.org/wiki/index.php/6b30]], runt-related transcription factor 3 (RUNX3)[[https://proteopedia.org/wiki/index.php/3mpm]], and B-cell lymphoma-6 (BCL6)[[https://proteopedia.org/wiki/index.php/3lbz]].These findings suggest that T-bet is a transcription factor that is critical for fine-tuning Th cell development. | ||
=== TBX21 as an antiasthmatic regulator === | === TBX21 as an antiasthmatic regulator === | ||
