Sandbox Reserved 1661: Difference between revisions

The hormone-binding extracellular domain consists of 250 amino acids, including several cysteine residues which are conserved and can form disulphide bridges.The intracellular domain of the receptor is made up of 350 amino acids, it represents the least conserved region and is made up of 10 tyrosine residues likely to be phosphorylated by tyrosine kinase ([https://en.wikipedia.org/wiki/Janus_kinase_2 JAK2]), during the formation of the GH-receptor complex. A reaction cascade involving kinase enzymes is then activated, allowing the expression of certain genes coding for proteins or not, necessary for biological activity [https://doi.org/10.1016/j.ygcen.2017.07.028 ]. It therefore controls the expression of certain genes such as the gene coding for the IGF-1 factor. The liver and adipose tissue being important targets for GH, it therefore contributes to [https://en.wikipedia.org/wiki/Homeostasis#:~:text=The%20neuroendocrine%20system%20is%20the,hypothalamic%20interconnections%20to%20other%20glands. metabolic homeostasis].<ref name="m/s"/> [https://doi.org/10.1016/j.ygcen.2017.07.028 ] The intercellular domain containing of two box regions. The proline rich first one and an acidic, hydrophobic second one which is connected to receptor internalizing mechanisms [https://doi.org/10.1016/j.ygcen.2017.07.028 ].   

== Dieseas and treatments  ==