Sandbox Reserved 1646: Difference between revisions
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=== Signal transduction === | === Signal transduction === | ||
Conformational rearrangements of common microswitches<ref>DOI: 10.7554/eLife.28505</ref> are characteristically influenced by the unusual ligand recognition and the absence of the cytoplasmic C-terminal helix. | Conformational rearrangements of common microswitches<ref>DOI: 10.7554/eLife.28505</ref> <ref>DOI: 10.1126/science.1150609</ref are characteristically influenced by the unusual ligand recognition and the absence of the cytoplasmic C-terminal helix. | ||
The transition of different GPCR conformation states is known to be mediated by water molecules by rearranging the conserved hydrophilic network formed by conserved amino acids in different helices43 | The transition of different GPCR conformation states is known to be mediated by water molecules by rearranging the conserved hydrophilic network formed by conserved amino acids in different helices43 | ||
Different motifs have already been identified to be critical for signal transmission in GnH1R. Noteworthy the hydrophobic Y6.51-Y6.52(TM6)-W6.48-F6.44 motif in TM6 and residues F2726.40 and Y3237.53. | Different motifs have already been identified to be critical for signal transmission in GnH1R. Noteworthy the hydrophobic Y6.51-Y6.52(TM6)-W6.48-F6.44 motif in TM6 and residues F2726.40 and Y3237.53. | ||
