1dl2: Difference between revisions

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[[Image:1dl2.gif|left|200px]]
{{Seed}}
[[Image:1dl2.png|left|200px]]


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{{STRUCTURE_1dl2|  PDB=1dl2  |  SCENE=  }}  
{{STRUCTURE_1dl2|  PDB=1dl2  |  SCENE=  }}  


'''CRYSTAL STRUCTURE OF CLASS I ALPHA-1,2-MANNOSIDASE FROM SACCHAROMYCES CEREVISIAE AT 1.54 ANGSTROM RESOLUTION'''
===CRYSTAL STRUCTURE OF CLASS I ALPHA-1,2-MANNOSIDASE FROM SACCHAROMYCES CEREVISIAE AT 1.54 ANGSTROM RESOLUTION===




==Overview==
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Mannose trimming is not only essential for N-glycan maturation in mammalian cells but also triggers degradation of misfolded glycoproteins. The crystal structure of the class I alpha1, 2-mannosidase that trims Man(9)GlcNAc(2) to Man(8)GlcNAc(2 )isomer B in the endoplasmic reticulum of Saccharomyces cerevisiae reveals a novel (alphaalpha)(7)-barrel in which an N-glycan from one molecule extends into the barrel of an adjacent molecule, interacting with the essential acidic residues and calcium ion. The observed protein-carbohydrate interactions provide the first insight into the catalytic mechanism and specificity of this eukaryotic enzyme family and may be used to design inhibitors that prevent degradation of misfolded glycoproteins in genetic diseases.
The line below this paragraph, {{ABSTRACT_PUBMED_10675327}}, adds the Publication Abstract to the page
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{{ABSTRACT_PUBMED_10675327}}


==About this Structure==
==About this Structure==
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[[Category: Yip, P.]]
[[Category: Yip, P.]]
[[Category: Alpha-alpha helix barrel]]
[[Category: Alpha-alpha helix barrel]]
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