6m49: Difference between revisions
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==== | ==cryo-EM structure of Scap/Insig complex in the present of 25-hydroxyl cholesterol.== | ||
<StructureSection load='6m49' size='340' side='right'caption='[[6m49]]' scene=''> | <StructureSection load='6m49' size='340' side='right'caption='[[6m49]], [[Resolution|resolution]] 3.70Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br> | <table><tr><td colspan='2'>[[6m49]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6M49 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6M49 FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6m49 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6m49 OCA], [https://pdbe.org/6m49 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6m49 RCSB], [https://www.ebi.ac.uk/pdbsum/6m49 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6m49 ProSAT]</span></td></tr> | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.7Å</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HC3:25-HYDROXYCHOLESTEROL'>HC3</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6m49 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6m49 OCA], [https://pdbe.org/6m49 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6m49 RCSB], [https://www.ebi.ac.uk/pdbsum/6m49 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6m49 ProSAT]</span></td></tr> | |||
</table> | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/INSI2_HUMAN INSI2_HUMAN] Mediates feedback control of cholesterol synthesis by controlling SCAP and HMGCR. Functions by blocking the processing of sterol regulatory element-binding proteins (SREBPs). Capable of retaining the SCAP-SREBF2 complex in the ER thus preventing it from escorting SREBPs to the Golgi. Seems to regulate the ubiquitin-mediated proteasomal degradation of HMGCR.<ref>PMID:12242332</ref> <ref>PMID:16606821</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: | [[Category: Brown AJ]] | ||
[[Category: Cao P]] | |||
[[Category: Coates HW]] | |||
[[Category: Du X]] | |||
[[Category: Gao S]] | |||
[[Category: Gong X]] | |||
[[Category: Lei J]] | |||
[[Category: Li Y]] | |||
[[Category: Liu X]] | |||
[[Category: Qian H]] | |||
[[Category: Song W]] | |||
[[Category: Sui J]] | |||
[[Category: Yan C]] | |||
[[Category: Yan N]] | |||
[[Category: Yan R]] | |||
[[Category: Yang H]] | |||
[[Category: Zhao X]] | |||
[[Category: Zhou Q]] | |||
Latest revision as of 10:48, 27 March 2024
cryo-EM structure of Scap/Insig complex in the present of 25-hydroxyl cholesterol.
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