6q1b: Difference between revisions
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==Crystal structure of oxidized iodotyrosine deiodinase (IYD) bound to FMN and 3-fluoro-L-tyrosine== | ==Crystal structure of oxidized iodotyrosine deiodinase (IYD) bound to FMN and 3-fluoro-L-tyrosine== | ||
<StructureSection load='6q1b' size='340' side='right'caption='[[6q1b]]' scene=''> | <StructureSection load='6q1b' size='340' side='right'caption='[[6q1b]], [[Resolution|resolution]] 1.60Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6Q1B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6Q1B FirstGlance]. <br> | <table><tr><td colspan='2'>[[6q1b]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermotoga_neapolitana_DSM_4359 Thermotoga neapolitana DSM 4359]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6Q1B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6Q1B FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6q1b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6q1b OCA], [https://pdbe.org/6q1b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6q1b RCSB], [https://www.ebi.ac.uk/pdbsum/6q1b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6q1b ProSAT]</span></td></tr> | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.596Å</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene>, <scene name='pdbligand=YOF:3-FLUOROTYROSINE'>YOF</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6q1b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6q1b OCA], [https://pdbe.org/6q1b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6q1b RCSB], [https://www.ebi.ac.uk/pdbsum/6q1b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6q1b ProSAT]</span></td></tr> | |||
</table> | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/IYD_THENN IYD_THENN] Catalyzes the dehalogenation of halotyrosines such as 3-bromo-L-tyrosine, 3-chloro-L-tyrosine, 3-iodo-L-tyrosine and 3,5-diiodo-L-tyrosine (PubMed:34748729). Activity towards 2-iodophenol is weak (PubMed:34748729).<ref>PMID:34748729</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Thermotoga neapolitana DSM 4359]] | |||
[[Category: Kavran JM]] | [[Category: Kavran JM]] | ||
[[Category: Rokita SE]] | [[Category: Rokita SE]] | ||
[[Category: Sun Z]] | [[Category: Sun Z]] | ||
