7ktp: Difference between revisions
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==== | ==PRC2:EZH1_B from a dimeric PRC2 bound to a nucleosome== | ||
<StructureSection load='7ktp' size='340' side='right'caption='[[7ktp]]' scene=''> | <StructureSection load='7ktp' size='340' side='right'caption='[[7ktp]], [[Resolution|resolution]] 4.80Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br> | <table><tr><td colspan='2'>[[7ktp]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7KTP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7KTP FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ktp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ktp OCA], [https://pdbe.org/7ktp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ktp RCSB], [https://www.ebi.ac.uk/pdbsum/7ktp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ktp ProSAT]</span></td></tr> | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 4.8Å</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ktp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ktp OCA], [https://pdbe.org/7ktp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ktp RCSB], [https://www.ebi.ac.uk/pdbsum/7ktp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ktp ProSAT]</span></td></tr> | |||
</table> | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/EZH1_HUMAN EZH1_HUMAN] Polycomb group (PcG) protein. Catalytic subunit of the PRC2/EED-EZH1 complex, which methylates 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. Able to mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. Required for embryonic stem cell derivation and self-renewal, suggesting that it is involved in safeguarding embryonic stem cell identity. Compared to EZH2-containing complexes, it is less abundant in embryonic stem cells, has weak methyltransferase activity and plays a less critical role in forming H3K27me3, which is required for embryonic stem cell identity and proper differentiation.<ref>PMID:19026781</ref> | |||
==See Also== | |||
*[[Histone methyltransferase 3D structures|Histone methyltransferase 3D structures]] | |||
*[[Polycomb complex proteins 3D structures|Polycomb complex proteins 3D structures]] | |||
*[[Retinoblastoma-binding protein 3D structures|Retinoblastoma-binding protein 3D structures]] | |||
== References == | |||
<references/> | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: | [[Category: Armache KJ]] | ||
[[Category: Grau DJ]] | |||
