Ubiquitin-fold modifier: Difference between revisions
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<StructureSection load='5iaa' size='340' side='right' caption='Human ubiquitin-fold modifier (pink, yellow) complex with ubiquitin-like modifier activating enzyme (green, grey) (PDB code [[5iaa]]' scene='' > | <StructureSection load='5iaa' size='340' side='right' caption='Human ubiquitin-fold modifier (pink, yellow) complex with ubiquitin-like modifier activating enzyme (green, grey) (PDB code [[5iaa]]' scene='' > | ||
== Function == | == Function == | ||
'''Ubiquitin-fold modifier''' (Ufm1) is a member of the ubiquitin-like family. Ufm1 is covalently attached to Lys residues of substrate proteins<ref>PMID:21494687</ref>. This attachment is called Ufmylation and requires '''Ubiquitin-like modifier activating enzyme''' (UBA5) and ''' | '''Ubiquitin-fold modifier''' (Ufm1) is a member of the ubiquitin-like family. Ufm1 is covalently attached to Lys residues of substrate proteins<ref>PMID:21494687</ref>. This attachment is called Ufmylation and requires '''Ubiquitin-like modifier activating enzyme''' (UBA5) and '''Ufm1-conjugating enzyme''' (Ufc1). Ufmylation is a type of post-translational modification that deals with fine-tuned and complex cellular activities and is involved in reticulophagy induced by ER stress<ref>PMID:31129212</ref>. Ufmylation is aribosomal modification specialized to facilitate metazoan-specific protein biogenesis at the ER<ref>PMID:30626644</ref>. | ||
== Relevance == | == Relevance == | ||
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*Ubiquitin-fold modifier | *Ubiquitin-fold modifier | ||
**[[5ia7]] – | **[[5ia7]] – hUfm1 - human<br /> | ||
**[[1wxs]] – | **[[1wxs]] – hUfm1 - NMR<br /> | ||
**[[5hkh]] – | **[[5hkh]] – hUfm1 + peptide<br /> | ||
**[[5iaa]] – | **[[5iaa]] – hUfm1 + UBA5<br /> | ||
**[[5l95]] – | **[[5l95]] – hUfm1 + UBA5 + AMP<br /> | ||
**[[6h77]] – | **[[6h77]] – hUfm1 + UBA5 + ATP<br /> | ||
**[[5xda]] – | **[[5xda]] – Ufm1 + Umf1-specific protease - ''Caenorhabditis elegans''<br /> | ||
**[[6izg]] – | **[[6izg]] – Ufm1 - ''Trypanosoma brucei'' - NMR<br /> | ||
