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| [[Image:1dn2.gif|left|200px]] | | {{Seed}} |
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| {{STRUCTURE_1dn2| PDB=1dn2 | SCENE= }} | | {{STRUCTURE_1dn2| PDB=1dn2 | SCENE= }} |
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| '''FC FRAGMENT OF HUMAN IGG1 IN COMPLEX WITH AN ENGINEERED 13 RESIDUE PEPTIDE DCAWHLGELVWCT-NH2'''
| | ===FC FRAGMENT OF HUMAN IGG1 IN COMPLEX WITH AN ENGINEERED 13 RESIDUE PEPTIDE DCAWHLGELVWCT-NH2=== |
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| ==Overview==
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| The hinge region on the Fc fragment of human immunoglobulin G interacts with at least four different natural protein scaffolds that bind at a common site between the C(H2) and C(H3) domains. This "consensus" site was also dominant for binding of random peptides selected in vitro for high affinity (dissociation constant, about 25 nanomolar) by bacteriophage display. Thus, this site appears to be preferred owing to its intrinsic physiochemical properties, and not for biological function alone. A 2.7 angstrom crystal structure of a selected 13-amino acid peptide in complex with Fc demonstrated that the peptide adopts a compact structure radically different from that of the other Fc binding proteins. Nevertheless, the specific Fc binding interactions of the peptide strongly mimic those of the other proteins. Juxtaposition of the available Fc-complex crystal structures showed that the convergent binding surface is highly accessible, adaptive, and hydrophobic and contains relatively few sites for polar interactions. These are all properties that may promote cross-reactive binding, which is common to protein-protein interactions and especially hormone-receptor complexes. | | The line below this paragraph, {{ABSTRACT_PUBMED_10678837}}, adds the Publication Abstract to the page |
| | (as it appears on PubMed at http://www.pubmed.gov), where 10678837 is the PubMed ID number. |
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| | {{ABSTRACT_PUBMED_10678837}} |
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| ==About this Structure== | | ==About this Structure== |
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| [[Category: Wells, J A.]] | | [[Category: Wells, J A.]] |
| [[Category: Fc igg phage display peptide]] | | [[Category: Fc igg phage display peptide]] |
| ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 14:02:34 2008'' | | |
| | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 23:19:20 2008'' |
