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==Solution structure of the first PAH domain of the mouse transcriptional repressor SIN3B==
==Solution structure of the first PAH domain of the mouse transcriptional repressor SIN3B==
<StructureSection load='2cr7' size='340' side='right'caption='[[2cr7]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
<StructureSection load='2cr7' size='340' side='right'caption='[[2cr7]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2cr7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CR7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CR7 FirstGlance]. <br>
<table><tr><td colspan='2'>[[2cr7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CR7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CR7 FirstGlance]. <br>
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">SIN3B ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2cr7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cr7 OCA], [https://pdbe.org/2cr7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2cr7 RCSB], [https://www.ebi.ac.uk/pdbsum/2cr7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2cr7 ProSAT], [https://www.topsan.org/Proteins/RSGI/2cr7 TOPSAN]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2cr7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cr7 OCA], [https://pdbe.org/2cr7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2cr7 RCSB], [https://www.ebi.ac.uk/pdbsum/2cr7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2cr7 ProSAT], [https://www.topsan.org/Proteins/RSGI/2cr7 TOPSAN]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/SIN3B_MOUSE SIN3B_MOUSE]] Acts as a transcriptional repressor. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Interacts with MAD-MAX heterodimers by binding to MAD. The heterodimer then represses transcription by tethering SIN3B to DNA. Also forms a complex with FOXK1 which represses transcription.<ref>PMID:7889570</ref> <ref>PMID:10620510</ref>
[https://www.uniprot.org/uniprot/SIN3B_MOUSE SIN3B_MOUSE] Acts as a transcriptional repressor. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Interacts with MAD-MAX heterodimers by binding to MAD. The heterodimer then represses transcription by tethering SIN3B to DNA. Also forms a complex with FOXK1 which represses transcription.<ref>PMID:7889570</ref> <ref>PMID:10620510</ref>  
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Lk3 transgenic mice]]
[[Category: Mus musculus]]
[[Category: Hayashi, F]]
[[Category: Hayashi F]]
[[Category: Nagashima, K]]
[[Category: Nagashima K]]
[[Category: Structural genomic]]
[[Category: Yokoyama S]]
[[Category: Yokoyama, S]]
[[Category: Yoshida M]]
[[Category: Yoshida, M]]
[[Category: Gene regulation]]
[[Category: National project on protein structural and functional analyse]]
[[Category: Nppsfa]]
[[Category: Paired amphipathic helix repeat]]
[[Category: Rsgi]]
[[Category: Transcriptional repressor]]
Retrieved from "https://proteopedia.org/2cr7"