2dak: Difference between revisions
From Proteopedia
Jump to navigationJump to search
No edit summary |
No edit summary |
||
| Line 1: | Line 1: | ||
==Solution Structure of the Second UBA Domain in the Human Ubiquitin Specific Protease 5 (Isopeptidase 5)== | ==Solution Structure of the Second UBA Domain in the Human Ubiquitin Specific Protease 5 (Isopeptidase 5)== | ||
<StructureSection load='2dak' size='340' side='right'caption='[[2dak | <StructureSection load='2dak' size='340' side='right'caption='[[2dak]]' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2dak]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/ | <table><tr><td colspan='2'>[[2dak]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DAK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2DAK FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2dak FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dak OCA], [https://pdbe.org/2dak PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2dak RCSB], [https://www.ebi.ac.uk/pdbsum/2dak PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2dak ProSAT], [https://www.topsan.org/Proteins/RSGI/2dak TOPSAN]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2dak FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dak OCA], [https://pdbe.org/2dak PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2dak RCSB], [https://www.ebi.ac.uk/pdbsum/2dak PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2dak ProSAT], [https://www.topsan.org/Proteins/RSGI/2dak TOPSAN]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[https://www.uniprot.org/uniprot/UBP5_HUMAN UBP5_HUMAN] Cleaves linear and branched multiubiquitin polymers with a marked preference for branched polymers. Involved in unanchored 'Lys-48'-linked polyubiquitin disassembly. Binds linear and 'Lys-63'-linked polyubiquitin with a lower affinity. Knock-down of USP5 causes the accumulation of p53/TP53 and an increase in p53/TP53 transcriptional activity because the unanchored polyubiquitin that accumulates is able to compete with ubiquitinated p53/TP53 but not with MDM2 for proteasomal recognition.<ref>PMID:19098288</ref> | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
| Line 27: | Line 26: | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Inoue M]] | |||
[[Category: Inoue | [[Category: Kigawa T]] | ||
[[Category: Kigawa | [[Category: Koshiba S]] | ||
[[Category: Koshiba | [[Category: Sato M]] | ||
[[Category: Yokoyama S]] | |||
[[Category: Sato | [[Category: Zhao C]] | ||
[[Category: Yokoyama | |||
[[Category: Zhao | |||
Latest revision as of 11:36, 22 May 2024
Solution Structure of the Second UBA Domain in the Human Ubiquitin Specific Protease 5 (Isopeptidase 5)
| ||||||||||||
