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==Solution structure of the RNA binding domain in heterogeneous nuclear ribonucleoprotein F homolog==
==Solution structure of the RNA binding domain in heterogeneous nuclear ribonucleoprotein F homolog==
<StructureSection load='2db1' size='340' side='right'caption='[[2db1]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
<StructureSection load='2db1' size='340' side='right'caption='[[2db1]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2db1]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DB1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2DB1 FirstGlance]. <br>
<table><tr><td colspan='2'>[[2db1]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DB1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2DB1 FirstGlance]. <br>
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">hnRNP F ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2db1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2db1 OCA], [https://pdbe.org/2db1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2db1 RCSB], [https://www.ebi.ac.uk/pdbsum/2db1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2db1 ProSAT], [https://www.topsan.org/Proteins/RSGI/2db1 TOPSAN]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2db1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2db1 OCA], [https://pdbe.org/2db1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2db1 RCSB], [https://www.ebi.ac.uk/pdbsum/2db1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2db1 ProSAT], [https://www.topsan.org/Proteins/RSGI/2db1 TOPSAN]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/HNRPF_MOUSE HNRPF_MOUSE]] Component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Plays a role in the regulation of alternative splicing events. Binds G-rich sequences in pre-mRNAs and keeps target RNA in an unfolded state (By similarity).  
[https://www.uniprot.org/uniprot/HNRPF_MOUSE HNRPF_MOUSE] Component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Plays a role in the regulation of alternative splicing events. Binds G-rich sequences in pre-mRNAs and keeps target RNA in an unfolded state (By similarity).
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Lk3 transgenic mice]]
[[Category: Mus musculus]]
[[Category: Abe, C]]
[[Category: Abe C]]
[[Category: Inoue, M]]
[[Category: Inoue M]]
[[Category: Kigawa, T]]
[[Category: Kigawa T]]
[[Category: Muto, Y]]
[[Category: Muto Y]]
[[Category: Structural genomic]]
[[Category: Shirouzu M]]
[[Category: Shirouzu, M]]
[[Category: Terada T]]
[[Category: Terada, T]]
[[Category: Yokoyama S]]
[[Category: Yokoyama, S]]
[[Category: National project on protein structural and functional analyse]]
[[Category: Nppsfa]]
[[Category: Rna binding protein]]
[[Category: Rrm domain]]
[[Category: Rsgi]]
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