2dj0: Difference between revisions
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==The solution structure of the thioredoxin domain of human Thioredoxin-related transmembrane protein 2== | ==The solution structure of the thioredoxin domain of human Thioredoxin-related transmembrane protein 2== | ||
<StructureSection load='2dj0' size='340' side='right'caption='[[2dj0 | <StructureSection load='2dj0' size='340' side='right'caption='[[2dj0]]' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2dj0]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/ | <table><tr><td colspan='2'>[[2dj0]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DJ0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2DJ0 FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2dj0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dj0 OCA], [https://pdbe.org/2dj0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2dj0 RCSB], [https://www.ebi.ac.uk/pdbsum/2dj0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2dj0 ProSAT], [https://www.topsan.org/Proteins/RSGI/2dj0 TOPSAN]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2dj0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dj0 OCA], [https://pdbe.org/2dj0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2dj0 RCSB], [https://www.ebi.ac.uk/pdbsum/2dj0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2dj0 ProSAT], [https://www.topsan.org/Proteins/RSGI/2dj0 TOPSAN]</span></td></tr> | ||
</table> | </table> | ||
== Disease == | |||
[https://www.uniprot.org/uniprot/TMX2_HUMAN TMX2_HUMAN] The disease is caused by variants affecting the gene represented in this entry. | |||
== Function == | |||
[https://www.uniprot.org/uniprot/TMX2_HUMAN TMX2_HUMAN] Endoplasmic reticulum and mitochondria-associated protein that probably functions as a regulator of cellular redox state and thereby regulates protein post-translational modification, protein folding and mitochondrial activity. Indirectly regulates neuronal proliferation, migration, and organization in the developing brain.<ref>PMID:31735293</ref> | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2dj0 ConSurf]. | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2dj0 ConSurf]. | ||
<div style="clear:both"></div> | <div style="clear:both"></div> | ||
== References == | |||
<references/> | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Inoue | [[Category: Inoue M]] | ||
[[Category: Kigawa | [[Category: Kigawa T]] | ||
[[Category: Koshiba | [[Category: Koshiba S]] | ||
[[Category: Tochio N]] | |||
[[Category: Tochio | [[Category: Yokoyama S]] | ||
[[Category: Yokoyama | |||
