2dm1: Difference between revisions
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==Solution structure of the second SH3 domain of human protein vav-2== | ==Solution structure of the second SH3 domain of human protein vav-2== | ||
<StructureSection load='2dm1' size='340' side='right'caption='[[2dm1 | <StructureSection load='2dm1' size='340' side='right'caption='[[2dm1]]' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2dm1]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/ | <table><tr><td colspan='2'>[[2dm1]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DM1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2DM1 FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2dm1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dm1 OCA], [https://pdbe.org/2dm1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2dm1 RCSB], [https://www.ebi.ac.uk/pdbsum/2dm1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2dm1 ProSAT], [https://www.topsan.org/Proteins/RSGI/2dm1 TOPSAN]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2dm1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dm1 OCA], [https://pdbe.org/2dm1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2dm1 RCSB], [https://www.ebi.ac.uk/pdbsum/2dm1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2dm1 ProSAT], [https://www.topsan.org/Proteins/RSGI/2dm1 TOPSAN]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[https://www.uniprot.org/uniprot/VAV2_HUMAN VAV2_HUMAN] Guanine nucleotide exchange factor for the Rho family of Ras-related GTPases. Plays an important role in angiogenesis. Its recruitment by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly (By similarity). | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Endo | [[Category: Endo H]] | ||
[[Category: Hayashi | [[Category: Hayashi F]] | ||
[[Category: Yokoyama S]] | |||
[[Category: Yokoyama | [[Category: Yoshida M]] | ||
[[Category: Yoshida | |||
Latest revision as of 18:43, 29 May 2024
Solution structure of the second SH3 domain of human protein vav-2
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