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==Left-handed G-quadruplex containing 3 bulges==
==Left-handed G-quadruplex containing 3 bulges==
<StructureSection load='7d5f' size='340' side='right'caption='[[7d5f]]' scene=''>
<StructureSection load='7d5f' size='340' side='right'caption='[[7d5f]], [[NMR_Ensembles_of_Models | 10 NMR models]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7D5F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7D5F FirstGlance]. <br>
<table><tr><td colspan='2'>[[7d5f]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7D5F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7D5F FirstGlance]. <br>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7d5f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7d5f OCA], [https://pdbe.org/7d5f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7d5f RCSB], [https://www.ebi.ac.uk/pdbsum/7d5f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7d5f ProSAT]</span></td></tr>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7d5f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7d5f OCA], [https://pdbe.org/7d5f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7d5f RCSB], [https://www.ebi.ac.uk/pdbsum/7d5f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7d5f ProSAT]</span></td></tr>
</table>
</table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
G-quadruplex (G4) DNA structures with a left-handed backbone progression have unique and conserved structural features. Studies on sequence dependency of the structures revealed the prerequisites and some minimal motifs required for left-handed G4 formation. To extend the boundaries, we explore the adaptability of left-handed G4s towards the existence of bulges. Here we present two X-ray crystal structures and an NMR solution structure of left-handed G4s accommodating one, two and three bulges. Bulges in left-handed G4s show distinct characteristics as compared to those in right-handed G4s. The elucidation of intricate structural details will help in understanding the possible roles and limitations of these unique structures.
Bulges in left-handed G-quadruplexes.,Das P, Ngo KH, Winnerdy FR, Maity A, Bakalar B, Mechulam Y, Schmitt E, Phan AT Nucleic Acids Res. 2021 Jan 27. pii: 6121459. doi: 10.1093/nar/gkaa1259. PMID:33503265<ref>PMID:33503265</ref>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 7d5f" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Bakalar B]]
[[Category: Bakalar, B]]
[[Category: Das P]]
[[Category: Das, P]]
[[Category: Maity A]]
[[Category: Maity, A]]
[[Category: Mechulam Y]]
[[Category: Mechulam, Y]]
[[Category: Ngo KH]]
[[Category: Ngo, K H]]
[[Category: Phan AT]]
[[Category: Phan, A T]]
[[Category: Schmitt E]]
[[Category: Schmitt, E]]
[[Category: Winnerdy FR]]
[[Category: Winnerdy, F R]]
[[Category: Bulge]]
[[Category: Dna]]
[[Category: G-quadruplex]]
[[Category: Left-handed]]
[[Category: Zg4]]
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