2eob: Difference between revisions

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==Solution structure of the second SH2 domain from rat PLC gamma-2==
==Solution structure of the second SH2 domain from rat PLC gamma-2==
<StructureSection load='2eob' size='340' side='right'caption='[[2eob]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
<StructureSection load='2eob' size='340' side='right'caption='[[2eob]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2eob]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EOB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2EOB FirstGlance]. <br>
<table><tr><td colspan='2'>[[2eob]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EOB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2EOB FirstGlance]. <br>
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Plcg2 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Phosphoinositide_phospholipase_C Phosphoinositide phospholipase C], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.4.11 3.1.4.11] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2eob FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2eob OCA], [https://pdbe.org/2eob PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2eob RCSB], [https://www.ebi.ac.uk/pdbsum/2eob PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2eob ProSAT], [https://www.topsan.org/Proteins/RSGI/2eob TOPSAN]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2eob FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2eob OCA], [https://pdbe.org/2eob PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2eob RCSB], [https://www.ebi.ac.uk/pdbsum/2eob PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2eob ProSAT], [https://www.topsan.org/Proteins/RSGI/2eob TOPSAN]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/PLCG2_RAT PLCG2_RAT]] The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. It is a crucial enzyme in transmembrane signaling.  
[https://www.uniprot.org/uniprot/PLCG2_RAT PLCG2_RAT] The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. It is a crucial enzyme in transmembrane signaling.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Buffalo rat]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Phosphoinositide phospholipase C]]
[[Category: Rattus norvegicus]]
[[Category: Hayashi, F]]
[[Category: Hayashi F]]
[[Category: Nagashima, T]]
[[Category: Nagashima T]]
[[Category: Structural genomic]]
[[Category: Sano R]]
[[Category: Sano, R]]
[[Category: Yokoyama S]]
[[Category: Yokoyama, S]]
[[Category: Yoshida M]]
[[Category: Yoshida, M]]
[[Category: Hydrolase]]
[[Category: National project on protein structural and functional analyse]]
[[Category: Nppsfa]]
[[Category: Phosphoinositide phospholipase c]]
[[Category: Phospholipase c-gamma-2]]
[[Category: Plc-gamma-2]]
[[Category: Plc-iv]]
[[Category: Rsgi]]
[[Category: Sh2]]